Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

被引：3

作者：

Benloucif, S ^{[1
]}

Masana, MI

Zee, PC

Dubocovich, ML

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Biol Chem & Mol Pharmacol, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

来源：

BRAIN RESEARCH | 2003年 / 966卷 / 01期

关键词：

calcium; calcium antagonist; phase delay; immediate early gene;

D O I：

10.1016/s0006-8993(02)04195-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：157 / 161

页数：5

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