Sex-Related Differences in Genetic Cardiomyopathies

被引：37

作者：

Argiro, Alessia ^{[1
,2
,3
]}

Ho, Carolyn ^{[4
]}

Day, Sharlene M. ^{[5
]}

van der Velden, Jolanda ^{[6
]}

Cerbai, Elisabetta ^{[7
]}

Saberi, Sara ^{[8
]}

Tardiff, Jil C. ^{[9
]}

Lakdawala, Neal K. ^{[4
]}

Olivotto, Iacopo ^{[1
,2
,3
]}

机构：

[1] Careggi Univ Hosp, Cardiomyopathy Unit, Florence, Italy

[2] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[3] Careggi Univ Hosp, Div Gen Cardiol, Florence, Italy

[4] Harvard Med Sch, Brigham & Womens Hosp, Cardiovasc Div, Boston, MA USA

[5] Univ Penn, Perelman Sch Med, Div Cardiovasc Med, Philadelphia, PA USA

[6] Vrije Univ, Amsterdam Univ Med Ctr, Dept Physiol, Amsterdam Cardiovasc Sci, Amsterdam, Netherlands

[7] Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

[8] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Michigan Med, Ann Arbor, MI USA

[9] Univ Arizona, Dept Biomed Engn, Tucson, AZ USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2022年 / 11卷 / 09期

基金：

欧盟地平线“2020”;

关键词：

cardiomyopathies; heart disease in women; heart failure; RIGHT-VENTRICULAR CARDIOMYOPATHY/DYSPLASIA; TRANSTHYRETIN CARDIAC AMYLOIDOSIS; FAMILIAL DILATED CARDIOMYOPATHY; GENDER-RELATED DIFFERENCES; HYPERTROPHIC CARDIOMYOPATHY; FABRY-DISEASE; MUTATIONS; FEMALES; REPOLARIZATION; CHANNELS;

D O I：

10.1161/JAHA.121.024947

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiomyopathies are a heterogeneous collection of diseases that have in common primary functional and structural abnormalities of the heart muscle, often genetically determined. The most effective categorization of cardiomyopathies is based on the presenting phenotype, with hypertrophic, dilated, arrhythmogenic, and restrictive cardiomyopathy as the prototypes. Sex modulates the prevalence, morpho-functional manifestations and clinical course of cardiomyopathies. Aspects as diverse as ion channel expression and left ventricular remodeling differ in male and female patients with myocardial disease, although the reasons for this are poorly understood. Moreover, clinical differences may also result from complex societal/environmental discrepancies between sexes that may disadvantage women. This review provides a state-of-the-art appraisal of the influence of sex on cardiomyopathies, highlighting the many gaps in knowledge and open research questions.

引用

页数：13

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