New steroidal alkaloid and furostanol glycosides isolated from Solanum lyratum with cytotoxicity

被引：15

作者：

Xu Yun-Ling ^{[1
]}

Lv Jia ^{[2
,3
]}

Wang Wei-Fang ^{[2
,3
]}

Liu Yue ^{[2
]}

Xu Ya-Juan ^{[2
,3
]}

Xu Tun-Hai ^{[1
]}

机构：

[1] Beijing Univ Tradit Chinese Med, Sch Chinese Pharm, Beijing 100029, Peoples R China

[2] Jilin Acad Chinese Med Sci, Key Lab Effect Subst Tradit Chinese Med, Changchun 130012, Jilin, Peoples R China

[3] Changchun Univ Tradit Chinese Med, Sch Tradit Chinese Med, Changchun 130031, Jilin, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2018年 / 16卷 / 07期

关键词：

Steroidal alkaloid; Furostanol glycoside; Solanum lyratum; Cytotoxic activity; SAPONINS; PLANTS; CONSTITUENTS; PARTS; THUNB;

D O I：

10.1016/S1875-5364(18)30085-2

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3 beta-ol- 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside (1) and 26-O-beta-D-glucopyranosyl-(25R)-5 alpha-furost20( 22)-en-3 beta, 26-diol (2), together with 7 known ones including 26-O-beta-D-glucopyranosyl-(25R)-5, 20(22)-dien-furost-3 beta, 26-diol (3), (25R)-5-en-spirost-3 beta-ol-O-beta-D-glucopyranosyl-(1 -> 4)-[alpha-L-rhmanopyranosyl-(1 -> 2)]-beta-D-galactopyranoside (4), funkioside D (5), aspidistrin (6), tigogenin-3-O-beta-D-lucotrioside (7), desglucolanatigonin II (8), and degalactotigonin (9), were isolated from Solanum lyratum Thunb. Their cytotoxic activities were tested in two cancer cell lines by MTT method. One of the steroidal glycosides (6) showed significant cytotoxic activity against gastric cancer SGC7901 and liver cancer BEL-7402 cells.

引用

页码：499 / 504

页数：6

共 17 条

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