Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension

被引：9

作者：

Ahn, Kye Taek ^{[1
]}

Park, Kwang-In ^{[1
]}

Kim, Mi Joo ^{[1
]}

Oh, Jin Kyung ^{[1
]}

Han, Ji Hye ^{[1
]}

Kwon, Hee Jin ^{[1
]}

Jin, Seon-Ah ^{[1
]}

Kim, Jun-Hyung ^{[1
]}

Park, Jae-Hyeong ^{[1
]}

Lee, Jae-Hwan ^{[1
]}

Choi, Si Wan ^{[1
]}

Seong, In-Whan ^{[1
]}

Jeong, Jin-Ok ^{[1
]}

机构：

[1] Chungnam Natl Univ, Dept Internal Med, Chungnam Natl Univ Hosp, Div Cardiol,Sch Med, 282 Munhwa Ro, Daejeon 35015, South Korea

来源：

CLINICAL INTERVENTIONS IN AGING | 2016年 / 11卷

基金：

新加坡国家研究基金会;

关键词：

hypertension; augmentation index; height; sex; ALL-CAUSE MORTALITY; ARTERIAL STIFFNESS; BLOOD-PRESSURE; CARDIOVASCULAR EVENTS; CENTRAL HEMODYNAMICS; WAVE REFLECTION; WOMEN; DISEASE; MEN; PREDICTION;

D O I：

10.2147/CIA.S101302

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. Methods: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (>= 135/85 mmHg) were enrolled. Central blood pressure and radial augmentation index (AIx) corrected for a heart rate of 75 bpm (radial AIx 75) were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. Results: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%). The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=-0.627 for height, R=0.035 for age, P-value =0.005), a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R-2=0.428, beta=6.237, 95% confidence interval [CI] for women 1.480-10.995, P-value =0.011 and beta=-0.632, 95% CI for height -0.929 to -0.335, P-value =0.009, respectively). Conclusion: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75.

引用

页码：415 / 422

页数：8

共 23 条

[1] Increased arterial rigidity in children affected by Cushing's syndrome after successful surgical cure [J].