Desferrioxamine and desferrioxamine-caffeine as carriers of aluminum and gallium to microbes via the Trojan Horse Effect

被引：21

作者：

Alvarado Huayhuaz, Jesus Antonio ^{[1
]}

Vitorino, Hector Aguilar ^{[1
]}

Campos, Othon Souto ^{[1
]}

Pires Serrano, Silvia Helena ^{[1
]}

Kaneko, Telma Mary ^{[2
]}

Esposito, Breno Pannia ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, SP, Brazil

来源：

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY | 2017年 / 41卷

基金：

巴西圣保罗研究基金会;

关键词：

Desferrioxamine; Aluminum; Gallium; Caffeine; Trojan horse; IRON CHELATORS; SIDEROPHORES; TRANSPORT; EQUILIBRIUM; DELIVERY; OVERLOAD; COMPLEX; CELLS;

D O I：

10.1016/j.jtemb.2017.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron acquisition by bacteria and fungi involves in several cases the promiscuous usage of siderophores. Thus, antibiotic resistance from these microorganisms can be circumvented through a strategy of loading toxic metals into siderophores (Trojan Horse Effect). Desferrioxamine (dfo) and its cell-permeant derivative desferrioxamine-caffeine (dfcaf) were complexed with aluminum or gallium for this purpose. The complexes Me(dfo) and Me(dfcaf) (Me = Al3+ and Ga3+) were synthesized and characterized by mass spectroscopy and cyclic voltammetry. Their relative stabilities were studied through competitive equilibria with fluorescent probes calcein, fluorescein-desferrioxamine and 8-hydroxyquinoline. Me(dfo) and Me(dfcaf) were consistently more toxic than free Me3+ against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans, demonstrating the Trojan Horse Effect. Wide spectrum antimicrobial action can be obtained by loading non-essential or toxic metal ions to microbes via a convenient siderophore carrier. (C) 2017 Elsevier GmbH. All rights reserved.

引用

页码：16 / 22

页数：7

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