Synthesis, Crystal Structure and Antifungal Activity of 8-Chloro-3-((4-chlorobenzyl)thio)[1,2,4]triazolo[4,3-a]pyridine

被引：0
作者：
Wang Qiao [1 ]
Zhai Zhi-Wen [1 ]
Sun Zhao-Hui [1 ]
Liu Xing-Hai [1 ]
Tan Cheng-Xia [1 ]
Weng Jian-Quan [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2016年 / 35卷 / 04期
基金：
中国国家自然科学基金;
关键词：
1,2,4-triazolo[4,3-a]pyridine; synthesis; crystal structure; antifungal activity; MICROWAVE-ASSISTED SYNTHESIS; ONE-POT SYNTHESIS; ANTICONVULSANT ACTIVITY; FUNGICIDAL ACTIVITY; DERIVATIVES; 1,2,3-THIADIAZOLE; DFT;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The title compound 8-chloro-3-((4-chlorobenzyl)thio)-[1,2,4]triazolo[4,3-a]pyridine was prepared from 1-chloro-4-(chloromethyl)benzene and 8-chloro-[1,2,4]triazolo[4,3-a]pyridine-3(2H)-thione in the presence of NaOH, and its structure was determined by X-ray diffraction analysis. The crystal is of triclinic system, space group P (1) over bar with a = 6.8264(6), b = 7.5890(4), c = 13.0960(7) angstrom, alpha = 93.447(4), beta = 98.772(6), gamma = 92.615(6)degrees, V = 668.26(8) angstrom(3), Z = 2, the final R = 0.035 and wR = 0.09 for 2259 observed reflections with I > 2 sigma(I). The preliminary biological test showed that the title compound has activities against Stemphylium lycopersici (Enjoji) Yamamoto, Fusarium oxysporum. sp. cucumebrium, and Botrytis cinerea with inhibitory to be 51.19%, 62.02% and 15.56%, respectively.
引用
收藏
页码：651 / 655
页数：5
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