Metabolic Syndrome Prevalence in Psoriasis

被引:3
作者
Parodi, Aurora [1 ,2 ]
Aste, Nicola [3 ]
Calvieri, Camilla [4 ]
Cantoresi, Franca [5 ]
Carlesimo, Marta [6 ]
Fabbri, Paolo [7 ]
Filosa, Giorgio [8 ]
Galluccio, Antonia [9 ]
Lisi, Paolo [10 ]
Micali, Giuseppe [11 ]
Potenza, Concetta [12 ]
Richetta, Antonio [5 ]
Simonacci, Marco [13 ]
Trevisan, Piergiusto [14 ]
Valenti, Giancarlo [15 ]
Calvieri, Stefano [5 ,16 ]
机构
[1] Univ Genoa, Dermatol Sect, Dipartimento Sci Salute DISSAL, Genoa, Italy
[2] S Martino Univ Hosp, Genoa, Italy
[3] Univ Cagliari, Dept Dermatol, Cagliari, Italy
[4] Univ Roma La Sapienza, Dept Clin & Mol Med, Sch Med & Psychol, AO StAndrea, I-00185 Rome, Italy
[5] Univ Roma La Sapienza, Dermatol Clin, I-00185 Rome, Italy
[6] Univ Roma La Sapienza, NESMOS Dept, AO StAndrea, I-00185 Rome, Italy
[7] Univ Florence, Dept Med & Surg Crit Care, Dermatol Sect, Florence, Italy
[8] A Murri Hosp, Dermatol Unit, Jesi, Italy
[9] Sacro Cuore di Gesu Fatebenefratelli Hosp, Dermatol Unit, Benevento, Italy
[10] Univ Perugia, Dermatol Clin, I-06100 Perugia, Italy
[11] Univ Catania, Dermatol Clin, Catania, Italy
[12] Univ Roma La Sapienza, Polo Pontino, Dermatol Unit, I-00185 Rome, Italy
[13] Macerata Hosp, Dermatol Unit, Macerata, Italy
[14] Univ Trieste, Dermatol Clin, Trieste, Italy
[15] UO Dermatol Catanzaro, Catanzaro, Italy
[16] Az Policlin Umberto I, UO Dermatol, I-00161 Rome, Italy
关键词
GLOBAL CARDIOVASCULAR RISK; DIABETES-MELLITUS; 3; DECADES; ASSOCIATION; DISEASE; MORTALITY; TRENDS; EPIDEMIOLOGY; HISTORY; OBESITY;
D O I
10.1007/s40257-014-0074-8
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The pathogenesis of psoriasis is complex, with a significant role suggested for pro-inflammatory mediators. There is strong evidence of an association between psoriasis and the metabolic syndrome (MetS), a cluster of cardiovascular risk factors, which impose a substantial disease burden. This study aimed to evaluate the prevalence of MetS and to examine the implications of disease severity, type 2 diabetes mellitus, and cardiovascular disease in a large cohort of Italian psoriatic patients representative of the whole population. This was a cross-sectional study involving 13 dermatological clinics in Italy. The primary study endpoint was a comparison of the prevalence of MetS between psoriatic patients and a non-psoriatic control group; secondary endpoints included the influence of psoriasis severity on the prevalence of MetS, and the relative prevalence and risk of type 2 diabetes mellitus and cardiovascular disorders. A total of 720 patients were enrolled (n = 360 per group). The prevalence of MetS was 26.84 % in the psoriatic population and 15.16 % in the control population (p = 0.0001; adjusted odds ratio 1.96). MetS was associated with a greater degree of psoriasis severity, and the prevalence and risk of diabetes tended to be higher in psoriatic patients than in the control group. In the Italian population, the prevalence of MetS and associated comorbidities is elevated in patients with psoriasis compared with non-psoriatic subjects, as has been demonstrated in other countries. Our findings reinforce the importance of considering the implications of metabolic comorbidities in treating patients with psoriasis.
引用
收藏
页码:371 / 377
页数:7
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