Crypt abscess-associated microbiota in inflammatory bowel disease and acute self-limited colitis

被引：12

作者：

Sokol, Harry ^{[1
]}

Vasquez, Nadia ^{[2
]}

Hoyeau-Idrissi, Nadia ^{[3
]}

Seksik, Philippe ^{[1
]}

Beaugerie, Laurent ^{[1
]}

Lavergne-Slove, Anne ^{[4
,5
]}

Pochart, Philippe ^{[2
]}

Marteau, Philippe ^{[2
,5
,6
]}

机构：

[1] Univ Paris 06, St Antoine Hosp, AP HP, Dept Gastroenterol & Nutr, F-75571 Paris, France

[2] CNAM, EA 3199, Biol Lab, F-75003 Paris, France

[3] Univ Paris 06, St Antoine Hosp, AP HP, Dept Pathol, F-75571 Paris, France

[4] Lariboisiere Hosp, Dept Pathol, F-75475 Paris, France

[5] Univ Paris 07, F-75475 Paris, France

[6] Lariboisiere Hosp, AP HP, Med Surg Dept Digest Dis, F-75475 Paris, France

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 05期

关键词：

Inflammatory bowel diseases; Crohn's disease; Ulcerative colitis; Crypt abscess; Microbiota; GRADIENT GEL-ELECTROPHORESIS; ILEAL CROHNS-DISEASE; 16S RIBOSOMAL-RNA; ULCERATIVE-COLITIS; FECAL MICROBIOTA; MUCOSA; DEFENSINS; IBD; EXPRESSION; BACTERIA;

D O I：

10.3748/wjg.v16.i5.583

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To evaluate whether crypt abscesses from inflammatory bowel disease (IBD) patients contain bacteria and to establish their nature. METHODS: We studied 17 ulcerative colitis patients, 11 Crohn's disease patients, 7 patients with acute self-limited colitis (ASLC) and normal colonic biopsies from 5 subjects who underwent colonoscopy for colon cancer screening. A fluorescent in situ hybridization technique was applied to colonic biopsies to assess the microbiota composition of the crypts and crypt abscesses. RESULTS: Crypts colonized by bacteria were observed in 42.9% and 3.6% of ASLC and IBD patients, respectively (P = 0.019). Crypt abscesses colonized by bacteria were observed in 28.6% and 0.0% of ASLC and IBD patients, respectively (P = 0.035). CONCLUSION: These results do not support the hypothesis that crypt abscesses in IBD are the result of localized dysbiosis arising from persistence of living bacteria colonizing the crypts. (C) 2010 Baishideng. All rights reserved.

引用

页码：583 / 587

页数：5

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