A novel coumarin-based water-soluble fluorescent probe for endogenously generated SO2 in living cells

被引：35
|
作者：
Yang, Jin [1 ]
Li, Kun [1 ]
Hou, Ji-Ting [1 ]
Lu, Chun-Yan [2 ]
Li, Ling-Ling [1 ]
Yu, Kang-Kang [1 ]
Yu, Xiao-Qi [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Radiol, Chengdu 610064, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2017年 / 60卷 / 06期
基金：
中国国家自然科学基金;
关键词：
endogenously generated SO2; fluorescent probe; bioimaging; SULFUR-DIOXIDE DERIVATIVES; CAPILLARY ELECTROPHORETIC DETERMINATION; THEORETICAL CALCULATIONS; AIR-POLLUTION; SULFITE; MITOCHONDRIA; BISULFITE; DESIGN; INJURY; DYES;
D O I：
10.1007/s11426-016-0411-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel coumarin-based "turn-on" fluorescent probe SS-1 was developed for selective detection of SO2 derivatives in 100% water solution among reactive sulfur species (RSS). The detection limit of the method was 91.7 nM. Moreover, the probe exhibited low cytotoxicity and was successfully applied in the imaging of endogenously generated SO2 in HeLa cells.
引用
收藏
页码：793 / 798
页数：6
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