MicroRNAs in ankylosing spondylitis: Function, potential and challenges

被引:23
作者
Motta, Francesca [1 ]
Carena, Maria Cristina [2 ,5 ]
Selmi, Carlo [1 ,3 ]
Vecellio, Matteo [1 ,4 ]
机构
[1] IRCCS, Div Rheumatol & Clin Immunol, Humanitas Res Hosp, Milan, Italy
[2] Humanitas Res Hosp, Milan, Italy
[3] Humanitas Univ, Dept Biomed Sci, Milan, Italy
[4] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England
[5] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy
关键词
MESSENGER-RNA EXPRESSION; BONE-FORMATION; DISEASE; PATHOGENESIS; CELL; DIFFERENTIATION; IDENTIFICATION; INFLAMMATION; BIOGENESIS; MECHANISM;
D O I
10.1016/j.jtauto.2020.100050
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA, are considered the essential connection between a disorder's onset and the environment, on a permissive genetic background. Among autoimmune and inflammatory-mediated disorders, Ankylosing Spondylitis (AS), a chronic arthritis of the spine, is a very good example for the weight of epigenetics' contribution. MicroRNAs (miRNAs) are single-stranded nucleotides which regulate gene expression and are involved in pathological and physiological processes. In this manuscript we provide a clarification on the role of microRNAs in AS, with a focus on the mechanisms of pathogenesis. In specific, we have examined the contribution of miRNAs in the processes of inflammation, new bone formation and T-cell function, and the pathways (i.e. Wnt, BMP, TGF beta signalling etc.) they regulate. The utility of miRNAs in better understanding AS pathogenesis is undisputed and their utility as therapeutic opportunity is strongly increasing.
引用
收藏
页数:6
相关论文
共 62 条
  • [1] The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas
    Adams, Brian D.
    Parsons, Christine
    Slack, Frank J.
    [J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2016, 20 (06) : 737 - 753
  • [2] MicroRNAs as biomarkers in rheumatic diseases
    Alevizos, Ilias
    Illei, Gabor G.
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2010, 6 (07) : 391 - 398
  • [3] The relationship between inflammation and new bone formation in patients with ankylosing spondylitis
    Baraliakos, Xenofon
    Listing, Joachim
    Rudwaleit, Martin
    Sieper, Joachim
    Braun, Juergen
    [J]. ARTHRITIS RESEARCH & THERAPY, 2008, 10 (05)
  • [4] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [5] HLA-B27
    Bowness, Paul
    [J]. ANNUAL REVIEW OF IMMUNOLOGY VOL 33, 2015, 33 : 29 - 48
  • [6] BREWERTON DA, 1973, LANCET, V1, P904
  • [7] Genetics of ankylosing spondylitis - insights into pathogenesis
    Brown, Matthew A.
    Kenna, Tony
    Wordsworth, B. Paul
    [J]. NATURE REVIEWS RHEUMATOLOGY, 2016, 12 (02) : 81 - 91
  • [8] miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis
    Chen, L.
    Al-Mossawi, M. H.
    Ridley, A.
    Sekine, T.
    Hammitzsch, A.
    de Wit, J.
    Simone, D.
    Shi, H.
    Penkava, F.
    Kurowska-Stolarska, M.
    Pulyakhina, I.
    Knight, J. C.
    Kim, T. J.
    Bowness, P.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (03) : 620 - 624
  • [9] Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA-B27
    Chen, Liye
    Fischer, Roman
    Peng, Yanchun
    Reeves, Emma
    McHugh, Kirsty
    Ternette, Nicola
    Hanke, Tomas
    Dong, Tao
    Elliott, Tim
    Shastri, Nilabh
    Kollnberger, Simon
    James, Edward
    Kessler, Benedikt
    Bowness, Paul
    [J]. ARTHRITIS & RHEUMATOLOGY, 2014, 66 (02) : 284 - 294
  • [10] Chua JH, 2009, CURR OPIN MOL THER, V11, P189