Lewy body variant of Alzheimer's disease:: α-synuclein in dystrophic neurites of Aβ plaques

被引：42
作者：
Wirths, O
Weickert, S
Majtenyi, K
Havas, L
Kahle, PJ
Okochi, M
Haass, C
Multhaup, G
Beyreuther, K
Bayer, TA
机构：
[1] Univ Bonn, Med Ctr, Dept Psychiat, D-53105 Bonn, Germany
[2] Inst Nervous & Mental Dis, Neuropathol Lab, H-111281 Budapest, Hungary
[3] Univ Munich, Dept Biochem, D-80336 Munich, Germany
[4] ZMBH, D-69120 Heidelberg, Germany
来源：
NEUROREPORT | 2000年 / 11卷 / 17期
关键词：
Alzheimer's disease; amyloid deposits; familial Alzheimer's disease; immunostaining; Lewy body; NAC; neuritic plaques; sporadic Alzheimer's disease; alpha-synuclein;
D O I：
10.1097/00001756-200011270-00029
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The contribution of alpha -synuclein accumulation in Alzheimer's disease (AD) plaques is currently a matter of scientific debate. In the present study antisera against the N- and C-terminus, the full-length protein and the central so-called non-amyloid component (NAC) domain of the alpha -synuclein protein were used to address this question in brains of cases with typical AD and of cases with the Lewy body (LB) variant of AD. In typical AD cases, none of the antisera revealed evidence for co-accumulation of alpha -synuclein with extracellular A beta peptides in plaques or in dystrophic neurites decorating the plaque core. Interestingly, cases with mixed pathology of the LB variant of AD revealed accumulation of alpha -synuclein in LBs and in dystrophic neurites of A beta plaques. NeuroReport 11:3737-3741 (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：3737 / 3741
页数：5
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