Hydroxyapatite-hybridized chitosan/chitin whisker bionanocomposite fibers for bone tissue engineering applications

被引：81

作者：

Pangon, Autchara ^{[1
]}

Saesoo, Somsak ^{[1
]}

Saengkrit, Nattika ^{[1
]}

Ruktanonchai, Uracha ^{[1
]}

Intasanta, Varol ^{[1
]}

机构：

[1] Natl Sci & Technol Dev Agcy, Natl Nanotechnol Ctr NANOTEC, Thailand Sci Pk, Pathum Thani 12120, Thailand

来源：

CARBOHYDRATE POLYMERS | 2016年 / 144卷

关键词：

Chitosan; Chitin whisker; Bionanocomposite; Hydroxyapatite; Electrospun nanofiber; Bone tissue engineering scaffold; BIOMEDICAL APPLICATIONS; CHITIN WHISKERS; CROSS-LINKING; COMPOSITE SCAFFOLDS; NANOFIBERS; FABRICATION; MEMBRANES; STIFFNESS; MINERALIZATION; NANOCOMPOSITES;

D O I：

10.1016/j.carbpol.2016.02.053

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Biomimetic nanofibrous scaffolds derived from natural biopolymers for bone tissue engineering applications require good mechanical and biological performances including biomineralization. The present work proposes the utility of chitin whisker (CTWK) to enhance mechanical properties of chitosan/poly(vinyl alcohol) (CS/PVA) nanofibers and to offer osteoblast cell growth with hydroxyapatite (HA) mineralization. By using diacid as a solvent, electrospun CS/PVA nanofibrous membranes containing CTWK can be easily obtained. The dimension stability of nanofibrous CS/PVA/CTWK bionanocomposite is further controlled by exposing to glutaraldehyde vapor. The nanofibrous membranes obtained allow mineralization of HA in concentrated simulated body fluid resulting in an improvement of Young's modulus and tensile strength. The CTWK combined with HA in bionanocomposite is a key to promote osteoblast cell adhesion and proliferation. The present work, for the first time, demonstrates the use of CTWKs for bionanocomposite fibers of chitosan and its hydroxyapatite biomineralization with the function in osteoblast cell culture. These hydroxyapatite-hybridized CS/PVA/CTWK bionanocomposite fibers (CS/PVA/CTWK-HA) offer a great potential for bone tissue engineering applications. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：419 / 427

页数：9