Multi-Stimuli-Responsive Polymer Particles, Films, and Hydrogels for Drug Delivery

被引：300
作者：
Fu, Xiao [1 ]
Hosta-Rigau, Leticia [2 ]
Chandrawati, Rona [3 ,4 ]
Cui, Jiwei [1 ]
机构：
[1] Shandong Univ, Key Lab Colloid & Interface Chem, Minist Educ, Sch Chem & Chem Engn, Jinan 250100, Shandong, Peoples R China
[2] Tech Univ Denmark, Dept Micro & Nanotechnol, Ctr Nanomed & Theranost, DTU Nanotech, Bldg 423, DK-2800 Lyngby, Denmark
[3] Univ New South Wales UNSW Sydney, Sch Chem Engn, Sydney, NSW 2052, Australia
[4] Univ New South Wales UNSW Sydney, Australian Ctr Nanomed, Sydney, NSW 2052, Australia
来源：
CHEM | 2018年 / 4卷 / 09期
基金：
中国国家自然科学基金; 澳大利亚研究理事会;
关键词：
BY-LAYER ASSEMBLIES; DUAL-PH; THERAPEUTIC DELIVERY; PHASE-TRANSITION; AQUEOUS-SOLUTION; LOGIC GATES; RELEASE; CAPSULES; POLY(N-ISOPROPYLACRYLAMIDE); NANOPARTICLES;
D O I：
10.1016/j.chempr.2018.07.002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Stimuli-responsive polymer materials are powerful tools in drug delivery and tissue engineering. Because of the large variations in physiological conditions between normal microenvironments and diseased sites, polymer materials with single responsiveness may not achieve the desired goals in a complex physiological microenvironment. Instead, polymer materials responsive to multiple physical or chemical stimuli are highly desired for biomedical applications (e.g., drug delivery). In this review, we highlight recent studies in multi-stimuli-responsive materials with a specific emphasis on polymer particles, films, and hydrogels. The synthetic strategies employed to produce these responsive materials are described. Applications in drug delivery are highlighted, followed by a discussion of the current research focus and future trends.
引用
收藏
页码：2084 / 2107
页数：24
相关论文
共 95 条
[11]   Multi-Stimuli-Responsive Polymer Materials: Particles, Films, and Bulk Gels [J].
Cao, Zi-Quan ;
Wang, Guo-Jie .
CHEMICAL RECORD, 2016, 16 (03) :1398-1435
[12]   Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma [J].
Chandrawati, Rona ;
Chang, Jason Y. H. ;
Reina-Torres, Ester ;
Jumeaux, Coline ;
Sherwood, Joseph M. ;
Stamer, W. Daniel ;
Zelikin, Alexander N. ;
Overby, Darryl R. ;
Stevens, Molly M. .
ADVANCED MATERIALS, 2017, 29 (16)
[13]   Enzyme-responsive polymer hydrogels for therapeutic delivery [J].
Chandrawati, Rona .
EXPERIMENTAL BIOLOGY AND MEDICINE, 2016, 241 (09) :972-979
[14]   Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors [J].
Chen, Jinjin ;
Ding, Jianxun ;
Wang, Yucai ;
Cheng, Jianjun ;
Ji, Shengxiang ;
Zhuang, Xiuli ;
Chen, Xuesi .
ADVANCED MATERIALS, 2017, 29 (32)
[15]   Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery [J].
Cheng, Ru ;
Meng, Fenghua ;
Deng, Chao ;
Klok, Harm-Anton ;
Zhong, Zhiyuan .
BIOMATERIALS, 2013, 34 (14) :3647-3657
[16]   Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities [J].
Cheng, Zhiliang ;
Al Zaki, Ajlan ;
Hui, James Z. ;
Muzykantov, Vladimir R. ;
Tsourkas, Andrew .
SCIENCE, 2012, 338 (6109) :903-910
[17]   Dual Stimuli-Responsive Polymeric Hollow Nanogels Designed as Carriers for Intracellular Triggered Drug Release [J].
Chiang, Wen-Hsuan ;
Viet Thang Ho ;
Huang, Wen-Chia ;
Huang, Yi-Fong ;
Chern, Chorng-Shyan ;
Chiu, Hsin-Cheng .
LANGMUIR, 2012, 28 (42) :15056-15064
[18]   Probing Bio-Nano Interactions with Templated Polymer Particles [J].
Cui, Jiwei .
CHEM, 2017, 2 (05) :606-607
[19]   Nanoengineered Templated Polymer Particles: Navigating the Biological Realm [J].
Cui, Jiwei ;
Richardson, Joseph J. ;
Bjornmalm, Mattias ;
Faria, Matthew ;
Caruso, Frank .
ACCOUNTS OF CHEMICAL RESEARCH, 2016, 49 (06) :1139-1148
[20]   Emerging methods for the fabrication of polymer capsules [J].
Cui, Jiwei ;
van Koeverden, Martin P. ;
Muellner, Markus ;
Kempe, Kristian ;
Caruso, Frank .
ADVANCES IN COLLOID AND INTERFACE SCIENCE, 2014, 207 :14-31
12345678910