The biology and therapeutic potential of interleukin 27

被引：104
作者：
Batten, Marcel
Ghilardi, Nico
机构：
[1] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
[2] Genentech Inc, San Francisco, CA 94080 USA
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2007年 / 85卷 / 07期
关键词：
IL-27; cytokines; T cell;
D O I：
10.1007/s00109-007-0164-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Interleukin (IL-) 27 is a helical cytokine of the greater IL-6/IL-12 family with a broad range of pro- and antiinflammatory properties. It can skew T helper cell development, suppress T cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B cells, and has diverse effects on innate immune cells. In vivo, its most important role appears to be that of immune regulation, as mice with defects in IL-27 or its receptor display enhanced immune responses in a range of infectious and noninfectious situations. In this review, we discuss the body of knowledge on IL-27 and its potential therapeutic utility.
引用
收藏
页码：661 / 672
页数：12
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