Renin and aldosterone determinations in hypertensive patients

被引：0

作者：

Hussein Tamas ^{[1
]}

Mezosi Emese ^{[1
]}

Bodis Beata ^{[1
]}

Nemes Orsolya ^{[1
]}

Rucz Karoly ^{[1
]}

Bajnok Laszlo ^{[1
]}

机构：

[1] Univ Pecs, Belgyogyaszati Klin 1, Pecs, Hungary

来源：

ORVOSI HETILAP | 2016年 / 157卷 / 21期

关键词：

hyperaldosteronism; primary aldosteronism; aldosteron/renin ratio; suppression aldosterone; diagnostic cut-off values; SCREENING-TEST; DOUBLE-BLIND; DIAGNOSIS; RATIO; SPIRONOLACTONE; PLACEBO;

D O I：

10.1556/650.2016.30348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: The diagnostic algorithm of primary aldosteronism is burdened with uncertainties and, recently, it has been suggested that the sensitivity of the aldosterone/renin ratio used as a screening test - based on the suppression aldosterone - is low. Aim: The primary aim was to test the accuracy of aldosterone/renin ratio. Method: In a retrospective analysis of 309 hypertensive patients supine and ambulatory aldosterone levels were independently examined. Results: Aldosterone/renin ratio was elevated in 99 patients of whom 31 exhibited elevated supine aldosterone, as well. In 34 cases supine aldosterone was increased without elevation of the aldosterone/renin ratio. However, only 3 of them had concomitant low renin levels indicating that primary aldosteronism could not be ruled out. Abnormally increased renin was found in 69 patients, but only 59% of them had increased aldosterone level. Conclusion: Sensitivity of aldosterone/renin ratio is high (91%) if used only in justified cases.

引用

页码：830 / 835

页数：6

共 18 条

[1] Bajnok L., 2009, HYPERTONIA NEPHROLOG, V13, P11
[2] Lessons from the novel renoprotective studies made by antihypertensive drugs
Bajnok, Laszlo
[J]. ORVOSI HETILAP, 2013, 154 (07) : 243 - 247
[3] Case detection, diagnosis, and treatment of patients with primary aldosteronism: An endocrine society clinical practice guideline
Funder, John W.
Carey, Robert M.
Fardella, Carlos
Gomez-Sanchez, Celso E.
Mantero, Franco
Stowasser, Michael
Young, William F., Jr.
Montori, Victor M.
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (09) : 3266 - 3281
[4] REEVALUATION OF THE CAPTOPRIL TEST FOR THE DIAGNOSIS OF PRIMARY HYPERALDOSTERONISM
HAMBLING, C
JUNG, RT
GUNN, A
BROWNING, MCK
BARTLETT, WA
[J]. CLINICAL ENDOCRINOLOGY, 1992, 36 (05) : 499 - 503
[5] Hungarian Society for Endocrinology and Metabolism, 2010, MAG END AN TARS AN U
[6] Test characteristics of the aldosterone-to-renin ratio as a screening test for primary aldosteronism
Jansen, Pieter M.
van den Born, Bert-Jan H.
Frenkel, Wijnanda J.
de Bruijne, Emile L. E.
Deinum, Jaap
Kerstens, Michiel N.
Smulders, Yvo M.
Woittiez, Arend Jan
Wijbenga, Johanna A. M.
Zietse, Robert
Danser, A. H. Jan
van den Meiracker, Anton H.
[J]. JOURNAL OF HYPERTENSION, 2014, 32 (01) : 115 - 126
[7] Kaplan N.M., 2015, Kaplan's Clinical Hypertension, V11th
[8] Primary aldosteronism: evidence against a second epidemic
Kaplan, Norman M.
[J]. JOURNAL OF HYPERTENSION, 2012, 30 (10) : 1899 - 1902
[9] Mancia G, 2007, EUR HEART J, V28, P1462, DOI [10.1093/eurheartj/ehm236, 10.1093/eurheartj/eht151]
[10] Aldosterone to renin ratio in a primary care setting: The Bussolengo study
Olivieri, O
Ciacciarelli, A
Signorelli, D
Pizzolo, F
Guarini, P
Pavan, C
Corgnati, A
Falcone, S
Corrocher, R
Micchi, A
Cressoni, C
Blengio, G
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) : 4221 - 4226

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