The Role of Amyloid PET in Imaging Neurodegenerative Disorders: A Review

被引:116
作者
Chapleau, Marianne [1 ]
Iaccarino, Leonardo [1 ]
Soleimani-Meigooni, David [1 ]
Rabinovici, Gil D. [1 ,2 ,3 ]
机构
[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
关键词
neurology; PET; PET/MRI; Alzheimer disease; amyloid PET; neurodegenerative diseases; ALZHEIMERS ASSOCIATION WORKGROUPS; POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; BETA PLAQUES; DISEASE; TAU; RECOMMENDATIONS; DECLINE;
D O I
10.2967/jnumed.121.263195
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Imaging of amyloid deposition using PET has been available in research studies for 2 decades and has been approved for clinical use by the U.S. Food and Drug Administration, the European Medicines Agency, and other regulatory agencies around the world. Amyloid PET is a crucial tool for the diagnosis of Alzheimer disease, as it allows the noninvasive detection of amyloid plaques, a core neuropathologic feature that defines the disease. The clinical use of amyloid PET is expected to increase with recent accelerated approval in the United States of aducanumab, an antiamyloid monoclonal antibody, for the treatment of mild cognitive impairment and mild dementia due to Alzheimer disease. However, amyloid pathology can also be found in cognitively unimpaired older adults and in patients with other neuro-degenerative disorders. The aim of this review is to provide an up-to-date overview of the application of amyloid PET in neurodegenerative diseases. We provide an in-depth analysis of the clinical, pathologic, and imaging correlates; a comparison with other available biomarkers; and a review of the application of amyloid PET in clinical trials and clinical utility studies.
引用
收藏
页码:13S / 19S
页数:7
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