A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release

被引:36
作者
Cui, Qinghua [1 ,2 ]
Thanh-Ha Le [1 ,2 ]
Lin, Yu-Jung [1 ,2 ]
Miao, Yang-Bao [1 ,2 ]
Sung, I-Ting [3 ]
Tsai, Wei-Bor [3 ]
Chan, Hao-Yu [1 ,2 ]
Lin, Zong-Hong [1 ,2 ]
Sung, Hsing-Wen [1 ,2 ]
机构
[1] Natl Tsing Hua Univ, Dept Chem Engn, Inst Biomed Engn, Hsinchu, Taiwan
[2] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu, Taiwan
[3] Natl Taiwan Univ, Dept Chem Engn, Taipei, Taiwan
关键词
Redox-active material; Micromotor; Galvanic cell; Self-powered battery; pH stimulus; TRIBOELECTRIC NANOGENERATOR; AGENTS; DYE;
D O I
10.1016/j.nanoen.2019.104120
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Most drug delivery vehicles lack thrust that propels them to disease sites for payload delivery. Herein, a microrod comprising a zinc (Zn) core and a positively-charged poly(3,4-ethylenedioxythiophene) (PEDOT+) shell incorporating an anionic model drug, which form a "galvanic cell" in an electrolyte solution, is proposed as a battery-driven drug delivery device. Upon immersion of the proposed Zn-based batteries in a physiological environment, two sets of redox reactions that compete with each other in a manner determined by the local pH occur spontaneously. At low pH, the reduction of H+ to H-2 bubbles, which are essential to propel the Zn batteries as micromotors, prevails, while at higher pH, the reduction of PEDOT to actuate galvanically payload release dominates. Observations in mice suggest that the self-powered Zn batteries may rapidly react and move in the gastric fluid after oral administration, considerably improving their penetration and retention in the mucus layer for localized drug release, similar to those directly injected into the subcutaneous tissue. None of the investigated tissues exhibits any significant inflammation or cell apoptosis, revealing that the developed Zn-based batteries have potential to serve as safe drug delivery devices.
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页数:8
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