Becoming a crossover-competent DSB

被引：15
作者：
Lake, Cathleen M. [1 ]
Hawley, R. Scott [1 ,2 ]
机构：
[1] Stowers Inst Med Res, 1000 E 50th St, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2016年 / 54卷
关键词：
Meiosis; Double-strand break; Crossover; Sumoylation; Ubiquitination; DOUBLE-STRAND BREAKS; MEIOTIC RECOMBINATION; SYNAPTONEMAL COMPLEX; ZMM PROTEINS; LIGASE HEI10; DNA; MEIOSIS; INTERFERENCE; SYNAPSIS; REVEALS;
D O I：
10.1016/j.semcdb.2016.01.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The proper execution of meiotic recombination (or crossing over) is essential for chromosome segregation during the first meiotic division, and thus this process is regulated by multiple, and often elaborate, mechanisms. Meiotic recombination begins with the programmed induction of DNA double-strand breaks (DSBs), of which only a subset are selected to be repaired into crossovers. This crossover selection process is carried out by a number of pro-crossover proteins that regulate the fashion in which DSBs are repaired. Here, we highlight recent studies regarding the process of DSB fate selection by a family of pro-crossover proteins known as the Zip-3 homologs. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：117 / 125
页数：9
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