Reaction mechanism and regulation of cystathionine β-synthase

被引：95

作者：

Banerjee, R ^{[1
]}

Evande, R ^{[1
]}

Kabil, Ö ^{[1
]}

Ojha, S ^{[1
]}

Taoka, S ^{[1
]}

机构：

[1] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2003年 / 1647卷 / 1-2期

关键词：

cystathionine beta-synthase; homocysteine; pyridoxal phosphate; heme; redox;

D O I：

10.1016/S1570-9639(03)00044-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammals, cystathionine beta-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the conversion of the essential amino acid, methionine, to cysteine. Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor. In this review, recent advances in our understanding of the kinetic mechanism of the yeast and human enzymes as well as pathogenic mutants of the human enzyme and insights into the role of heme in redox sensing are discussed from the perspective of the crystal structure of the catalytic core of the human enzyme. (C) 2003 Elsevier Science B.V. All rights reserved.

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页码：30 / 35

页数：6

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