Dummy run and conformity indices in the ongoing EORTC low-grade glioma trial 22033-26033: First evaluation of quality of radiotherapy planning

被引：17

作者：

Musat, Elena ^{[1
]}

Roelofs, Erik

Bar-Deroma, Raquel ^{[2
]}

Fenton, Paul ^{[3
]}

Gulyban, Akos ^{[3
]}

Collette, Laurence ^{[3
]}

Stupp, Roger ^{[4
]}

Weber, Damien C. ^{[5
]}

Davis, J. Bernard ^{[6
]}

Aird, Edwin ^{[7
]}

Baumert, Brigitta G.

机构：

[1] Rene Huguenin Hosp, Inst Curie, Dept Radiat Oncol, F-92210 St Cloud, France

[2] Rambam Med Ctr, Dept Oncol, Haifa, Israel

[3] EORTC Headquarters, Brussels, Belgium

[4] Univ Lausanne, CHU Vaudois, CH-1015 Lausanne, Switzerland

[5] Univ Hosp Geneva, Dept Radiat Oncol, Geneva, Switzerland

[6] Univ Zurich Hosp, Radiat Oncol Clin & Policlin, CH-8091 Zurich, Switzerland

[7] Mt Vernon Hosp, Dept Med Phys, Northwood HA6 2RN, Middx, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2010年 / 95卷 / 02期

关键词：

Conformal radiotherapy; Dummy run; Conformity indices; Low-grade gliomas; Homogeneity; Quality assurance; RADIATION-THERAPY; RANDOMIZED-TRIAL; EUROPEAN ORGANIZATION; CANCER-TREATMENT; ASSURANCE; ONCOLOGY; TEMOZOLOMIDE;

D O I：

10.1016/j.radonc.2010.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Early assessment of radiotherapy (RT) quality in the ongoing EORTC trial comparing primary temozolomide versus RT in low-grade gliomas. Materials and methods: RT plans provided for dummy cases were evaluated and compared against expert plans. We analysed: (1) tumour and organs-at-risk delineation, (2) geometric and dosimetric characteristics, (3) planning parameters, compliance with dose prescription and Dmax for OAR (4) indices: RTOG conformity index (CI), coverage factor (CF), tissue protection factor (PF); conformity number (CN = PF x CF); dose homogeneity in PTV (U). Results: Forty-one RT plans were evaluated. Only two (5%) centres were requested to repeat CTV-PTV delineations. Three (7%) plans had a significant under-dosage and dose homogeneity in one deviated >10%. Dose distribution was good with mean values of 1.5, 1, 0.68, and 0.68 (ideal values = 1) for CI, CF, PF, and CN, respectively. CI and CN strongly correlated with PF and they correlated with PTV. Planning with more beams seems to increase PTVDmin, improving CF. U correlated with PTVDmax. Conclusion: Preliminary results of the dummy run procedure indicate that most centres conformed to protocol requirements. To quantify plan quality we recommend systematic calculation of U and either CI or CN, both of which measure the amount of irradiated normal brain tissue. (C) 2010 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 95 (2010) 218-224

引用

页码：218 / 224

页数：7

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