Statin therapy and plasma cortisol concentrations: A systematic review and meta-analysis of randomized placebo-controlled trials

被引：29

作者：

Sahebkar, Amirhossein ^{[1
,2
]}

Rathouska, Jana ^{[3
]}

Simental-Mendia, Luis E. ^{[4
]}

Nachtigal, Petr ^{[3
]}

机构：

[1] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran

[2] Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp, Metab Res Ctr, Perth, WA 6009, Australia

[3] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Biol & Med Sci, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic

[4] Mexican Social Secur Inst, Biomed Res Unit, Durango, Mexico

来源：

PHARMACOLOGICAL RESEARCH | 2016年 / 103卷

关键词：

Statin; Cortisol level; Meta-analysis; Randomized controlled trial; LOW SERUM-CHOLESTEROL; C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION; ADHESION MOLECULES; SIMVASTATIN; EXPRESSION; ROSUVASTATIN; STRESS; HYPERCHOLESTEROLEMIA; LOVASTATIN;

D O I：

10.1016/j.phrs.2015.10.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aimed to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) in order to calculate the effect size of statin therapy in changing plasma cortisol concentrations. Following a systematic search in Medline, SCOPUS, Web of Science and Google Scholar databases (by up to March 01, 2015), 7 eligible RCTs were selected. Random-effects meta-analysis suggested a significant increase in plasma cortisol concentrations following statin therapy (WMD: 6.34%, 95% CI: 1.80, 10.87, p = 0.006). Subgroup analysis confirmed the significance of the effect with lipophilic statins comprising atorvastatin, simvastatin, and lovastatin (WMD: 7.00%, 95% CI: 2.21, 11.79, p = 0.004) but not with hydrophilic statins (rosuvastatin and pravastatin) (WMD: 0.60%, 95% CI: 13.46, 14.66, p = 0.933). In the meta-regression analysis, changes in plasma cortisol concentrations following statin therapy were found to be independent of treatment duration. Results of this meta-analysis of RCTs suggest a significant elevation in plasma cortisol levels following statin therapy. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：17 / 25

页数：9

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