Lactide: Production Routes, Properties, and Applications

被引：32

作者：

Cunha, Bruna L. C. ^{[1
]}

Bahu, Juliana O. ^{[2
]}

Xavier, Leticia F. ^{[1
]}

Crivellin, Sara ^{[2
]}

de Souza, Samuel D. A. ^{[2
]}

Lodi, Leandro ^{[3
]}

Jardini, Andre L. ^{[2
]}

Maciel Filho, Rubens ^{[2
]}

Schiavon, Maria I. R. B. ^{[2
]}

Concha, Viktor O. Cardenas ^{[1
]}

Severino, Patricia ^{[4
,5
]}

Souto, Eliana B. ^{[6
,7
]}

机构：

[1] Fed Univ Sao Paulo UNIFESP, Sch Chem Engn, BR-09913030 Diadema, SP, Brazil

[2] Univ Campinas UNICAMP, Sch Chem Engn, BR-13083852 Campinas, SP, Brazil

[3] Fed Univ Alfenas UNIFAL, Inst Sci & Technol, BR-37715400 Pocos De Caldas, MG, Brazil

[4] Inst Technol & Res ITP, Lab Nanotechnol & Nanomed LNMed, Ave Murilo Dantas 300, BR-49010390 Aracaju, Sergipe, Brazil

[5] Univ Tiradentes UNIT, Ind Biotechnol Program, Ave Murilo Dantas 300, BR-49010390 Aracaju, Sergipe, Brazil

[6] Univ Porto, Dept Pharmaceut Technol, Fac Pharm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[7] Univ Porto, REQUIMTE UCIBIO, Fac Pharm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

来源：

BIOENGINEERING-BASEL | 2022年 / 9卷 / 04期

关键词：

applications; industrial processes; l-lactide; market costs; synthesis;

D O I：

10.3390/bioengineering9040164

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lactide dimer is an important monomer produced from lactic acid dehydration, followed by the prepolymer depolymerization process, and subsequent purification. As lactic acid is a chiral molecule, lactide can exist in three isomeric forms: L-, D-, and meso-lactide. Due to its time-consuming synthesis and the need for strict temperature and pressure control, catalyst use, low selectivity, high energy cost, and racemization, the value of a high purity lactide has a high cost in the market; moreover, little is found in scientific articles about the monomer synthesis. Lactide use is mainly for the synthesis of high molar mass poly(lactic acid) (PLA), applied as bio-based material for medical applications (e.g., prostheses and membranes), drug delivery, and hydrogels, or combined with other polymers for applications in packaging. This review elucidates the configurations and conditions of syntheses mapped for lactide production, the main properties of each of the isomeric forms, its industrial production, as well as the main applications in the market.

引用

页数：21

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