Estrogen as an immunomodulator

被引：196

作者：

Lang, TJ ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Div Clin Immunol & Rheumatol, Baltimore, MD 21201 USA

来源：

CLINICAL IMMUNOLOGY | 2004年 / 113卷 / 03期

关键词：

autoimmunity; T cells; B cells; antigen-presenting cells; estrogen;

D O I：

10.1016/j.clim.2004.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Estrogen's role in the sex differences observed in autoimmune diseases such as systemic lupus, multiple sclerosis, and rheumatoid arthritis have remained unclear. Complicating the understanding of the immunomodulatory effects of estrogen are (1) the effects of estrogen on multiple components of the immune response; (2) its varied effects on different systems in which it appears pro-autoimmune, as in murine Jupus, or anti-inflammatory, as in EAE; and (3) its effects on other hormones which are potentially immunomodulatory. Recent reports have shed light on the role of estrogen in the modulation of lymphocyte survival and expansion and in the elaboration of Th1 versus Th2 cytokines and on the mechanisms by which estrogen can activate via multiple signaling and genomic pathways in immune cells. (C) 2004 Published by Elsevier Inc.

引用

页码：224 / 230

页数：7

共 60 条

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