Radiotherapy and Renal Cell Carcinoma: A Continuing Saga

被引：12

作者：

Spyropoulou, Despoina ^{[1
]}

Tsiganos, Panagiotis ^{[2
]}

Dimitrakopoulos, Foteinos-Ioannis ^{[3
,4
]}

Tolia, Maria ^{[5
]}

Koutras, Angelos ^{[3
]}

Velissaris, Dimitris ^{[6
,7
]}

Lagadinou, Maria ^{[6
]}

Papathanasiou, Nikolaos ^{[8
]}

Gkantaifi, Areti ^{[9
]}

Kalofonos, Haralabos ^{[3
]}

Kardamakis, Dimitrios ^{[1
]}

机构：

[1] Univ Patras, Med Sch, Dept Radiat Oncol, Univ Campus, Patras 26504, Greece

[2] Univ Patras, Dept Med, Clin Radiol Lab, Patras, Greece

[3] Univ Hosp Patras, Dept Med, Div Oncol, Patras, Greece

[4] Univ Patras, Med Sch, Clin & Mol Oncol Lab, Patras, Greece

[5] Univ Crete, Med Sch, Univ Hosp Heraklion, Radiotherapy Dept, Iraklion, Greece

[6] Univ Hosp Patras, Emergency Dept, Patras, Greece

[7] Univ Hosp Patras, Internal Med Dept, Patras, Greece

[8] Univ Hosp Patras, Nucl Med & PET CT Dept, Patras, Greece

[9] Interbalkan Med Ctr, Radiotherapy Dept, Thessaloniki, Greece

来源：

IN VIVO | 2021年 / 35卷 / 03期

关键词：

Renal cell cancer; radiotherapy; radioresistance; radiosensitivity; oligometastatic disease; stereotactic body radiation therapy; review; EXTERNAL-BEAM RADIOTHERAPY; STEREOTACTIC BODY RADIOTHERAPY; LONG-TERM OUTCOMES; BRAIN METASTASES; POSTOPERATIVE RADIOTHERAPY; RADIATION-THERAPY; RANDOMIZED-TRIAL; PROGNOSTIC-FACTORS; SYSTEMIC THERAPY; STAGE-II;

D O I：

10.21873/invivo.12389

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Renal cell carcinoma (RCC) is one of the most aggressive malignancies of the genito-urinary tract, having a poor prognosis especially in patients with metastasis. Surgical resection remains the gold standard for localized renal cancer disease, with radiotherapy (RT) receiving much skepticism during the last decades. However, many studies have evaluated the role of RT, and although renal cancer is traditionally considered radio-resistant, technological advances in the RT field with regards to modern linear accelerators, as well as advanced RT techniques have resulted in breakthrough therapeutic outcomes. Additionally, the combination of RT with immune checkpoint inhibitors and targeted agents may maximize the clinical benefit. This review article focuses on the role of RT in the therapeutic management of renal cell carcinoma.

引用

页码：1365 / 1377

页数：13

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