Teratogens: a public health issue - a Brazilian overview

被引:0
作者
Mazzu-Nascimento, Thiago [1 ,2 ]
Melo, Debora Gusmao [3 ]
Morbioli, Giorgio Gianini [1 ,2 ,4 ]
Carrilho, Emanuel [1 ,2 ]
Luiz Vianna, Fernanda Sales [5 ,6 ]
da Silva, Andre Anjos [5 ,7 ]
Schuler-Faccini, Lavinia [5 ,6 ]
机构
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP, Brazil
[2] Inst Nacl Ciencia & Tecnol Bioanalit, Campinas, SP, Brazil
[3] Univ Fed Sao Carlos, Dept Med, Ctr Ciencias Biol & Saude, Sao Carlos, SP, Brazil
[4] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
[5] Hosp Clin Porto Alegre, Sistema Nacl Informacao Agentes Teratogen SIAT, Porto Alegre, RS, Brazil
[6] Univ Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, Programa Posgrad Genet & Biol Mol, Porto Alegre, RS, Brazil
[7] UNIVATES Univ, Lajeado, RS, Brazil
基金
巴西圣保罗研究基金会;
关键词
Birth defects; teratogens; Zika virus; pregnancy; public health; ZIKA VIRUS; BIRTH-DEFECTS; CONGENITAL-MALFORMATIONS; THALIDOMIDE EMBRYOPATHY; SEXUAL TRANSMISSION; INFANT-MORTALITY; SOUTHERN BRAZIL; UNITED-STATES; RISK-FACTORS; EXPOSURE;
D O I
10.1590/1678-4685-GMB-2016-0179
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Congenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more frequently observed. Here, we address the environmental causes of birth defects-or teratogens - as a public health issue and present their mechanisms of action, categories and their respective maternal-fetal deleterious effects. We also present a survey from 2008 to 2013 of Brazilian cases involving congenital anomalies (annual average of 20,205), fetal deaths (annual average of 1,530), infant hospitalizations (annual average of 82,452), number of deaths of hospitalized infants (annual average of 2,175), and the average cost of hospitalizations (annual cost of $7,758). Moreover, we report on Brazilian cases of teratogenesis due to the recent Zika virus infection, and to the use of misoprostol, thalidomide, alcohol and illicit drugs. Special attention has been given to the Zika virus infection, now proven to be responsible for the microcephaly outbreak in Brazil, with 8,039 cases under investigation (from October 2015 to June 2016). From those cases, 1,616 were confirmed and 324 deaths occurred due to microcephaly complications or alterations on the central nervous system. Congenital anomalies impact life quality and raise costs in specialized care, justifying the classification of teratogens as a public health issue.
引用
收藏
页码:387 / 397
页数:11
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