Menopause and the Risk of Developing Age-Related Macular Degeneration in Korean Women

被引：5
作者：
Yuk, Jin-Sung [1 ]
Hwang, Je Hyung [2 ]
机构：
[1] Inje Univ, Sanggye Paik Hosp, Dept Obstet & Gynecol, 1342 Dongil Ro, Seoul 139707, South Korea
[2] Inje Univ, Sanggye Paik Hosp, Dept Ophthalmol, 1342 Dongil Ro, Seoul 139707, South Korea
来源：
JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 07期
关键词：
age-related macular degeneration; cohort study; diabetes mellitus; menopause; risk factors; REPRODUCTIVE FACTORS; VISUAL IMPAIRMENT; HORMONE REPLACEMENT; EYE DISEASE; ESTROGEN; GENDER; ASSOCIATION; POPULATION; PREVALENCE; BLINDNESS;
D O I：
10.3390/jcm11071899
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Previous studies have shown that menopausal hormone therapy in postmenopausal women results in a higher prevalence of age-related macular degeneration. This study aimed to evaluate the effects of menopause and patient factors on the development of age-related macular degeneration in Korean women. Data between 2011 and 2014 were collected from the Korean National Health Insurance database. In this retrospective cohort study, 97,651 participants were premenopausal and 33,598 were menopausal. Participants were divided into menopausal and premenopausal groups to analyze the risk factors associated with the development of age-related macular degeneration. The prevalence of age-related macular degeneration was compared between the two groups. Other patient factors were also analyzed. Using a 1:1 propensity score matching method and adjusting for variables, the incidence of age-related macular degeneration was not significantly different between the two groups. Age and diabetes mellitus were associated with an increased risk of developing age-related macular degeneration, regardless of menopause. Menopause was not a risk factor for age-related macular degeneration. These findings may help physicians identify women with diabetes who are at a greater risk of developing age-related macular degeneration.
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页数：9
相关论文
共 30 条
[11]  
Klein B E, 1994, Trans Am Ophthalmol Soc, V92, P289
[12]   Reproductive exposures, incident age-related cataracts, and age-related maculopathy in women: The Beaver Dam Eye Study [J].
Klein, BEK ;
Klein, R ;
Lee, KE .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2000, 130 (03) :322-326
[13]   Ten-year incidence and progression of age-related maculopathy [J].
Klein, R ;
Klein, BEK ;
Tomany, SC ;
Meuer, SM ;
Huang, GH .
OPHTHALMOLOGY, 2002, 109 (10) :1767-1779
[14]   Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium [J].
Marin-Castaño, ME ;
Elliot, SJ ;
Potier, M ;
Karl, M ;
Striker, LJ ;
Striker, GE ;
Csaky, KG ;
Cousins, SW .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (01) :50-59
[15]   The association between statin use and age related maculopathy [J].
McGwin, G ;
Owsley, C ;
Curcio, CA ;
Crain, RJ .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2003, 87 (09) :1121-1125
[16]   Female reproductive factors and eye disease in a rural south Indian population: The Aravind Comprehensive Eye Survey [J].
Nirmalan, PK ;
Katz, J ;
Robin, AL ;
Ramakrishnan, R ;
Krishnadas, R ;
Thulasiraj, RD ;
Tielsch, JM .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 (12) :4273-4276
[17]  
Ogueta SB, 1999, INVEST OPHTH VIS SCI, V40, P1906
[18]   TOPOGRAPHIC CHANGES IN CHOROIDAL THICKNESS IN AGE-RELATED MACULAR DEGENERATION DURING THE DEVELOPMENT OF ACTIVE CHOROIDAL NEOVASCULARIZATION [J].
Park, Jae Yong ;
Kang, Min-Ji ;
Kim, Bum Gi ;
Chung, Kyu Ho ;
Sim, Ha Eun ;
Lee, Seong Woo ;
Kim, Jae Suk ;
Lee, Hyeon Seok ;
Hwang, Je Hyung .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2021, 41 (02) :409-422
[19]   Hormone Therapy as a Protective Factor for Age-Related Macular Degeneration [J].
Patnaik, Jennifer L. ;
Lynch, Anne M. ;
Wagner, Brandie D. ;
Echalier, E. Lacey ;
Kohrt, Wendy M. ;
Mathias, Marc T. ;
Siringo, Frank S. ;
Palestine, Alan G. ;
Mandava, Naresh .
OPHTHALMIC EPIDEMIOLOGY, 2020, 27 (02) :148-154
[20]  
Resnikoff S, 2004, B WORLD HEALTH ORGAN, V82, P844
123