LAP proteins: what's up with epithelia?

被引:52
作者
Bryant, PJ [1 ]
Huwe, A [1 ]
机构
[1] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92697 USA
关键词
D O I
10.1038/35019616
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
How cells maintain their overall shape and size, and the related question of how proteins and other molecules reach and stay at their specific subcellular locations, are among the most difficult and exciting problems in cell biology. Three recent studies have made a significant contribution to this area by identifying new proteins, called LAP proteins that have critical functions in maintaining the shape and apical-basal polarity of epithelial cells.
引用
收藏
页码:E141 / E143
页数:3
相关论文
共 18 条
  • [1] Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
    Bilder, D
    Perrimon, N
    [J]. NATURE, 2000, 403 (6770) : 676 - 680
  • [2] Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    Bilder, D
    Li, M
    Perrimon, N
    [J]. SCIENCE, 2000, 289 (5476) : 113 - 116
  • [3] ERBIN:: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor
    Borg, JP
    Marchetto, S
    Le Bivic, A
    Ollendorff, V
    Jaulin-Bastard, F
    Saito, H
    Fournier, E
    Adélaïde, J
    Margolis, B
    Birnbaum, D
    [J]. NATURE CELL BIOLOGY, 2000, 2 (07) : 407 - 414
  • [4] Bryant PJ, 1997, DEV GENET, V20, P75, DOI 10.1002/(SICI)1520-6408(1997)20:2<75::AID-DVG1>3.0.CO
  • [5] 2-5
  • [6] Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition
    Daniels, DL
    Cohen, AR
    Anderson, JM
    Brünger, AT
    [J]. NATURE STRUCTURAL BIOLOGY, 1998, 5 (04) : 317 - 325
  • [7] PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane
    Fanning, AS
    Anderson, JM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) : 767 - 772
  • [8] The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses
    Garcia, RAG
    Vasudevan, K
    Buonanno, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) : 3596 - 3601
  • [9] HANADA T, IN PRESS J BIOL CHEM
  • [10] Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large
    Hough, CD
    Woods, DF
    Park, S
    Bryant, PJ
    [J]. GENES & DEVELOPMENT, 1997, 11 (23) : 3242 - 3253