An Overview of the Molecular Mechanisms Associated with Myocardial Ischemic Injury: State of the Art and Translational Perspectives

被引：69

作者：

Schirone, Leonardo ^{[1
]}

Forte, Maurizio ^{[2
]}

D'Ambrosio, Luca ^{[1
]}

Valenti, Valentina ^{[1
]}

Vecchio, Daniele ^{[1
]}

Schiavon, Sonia ^{[1
]}

Spinosa, Giulia ^{[1
]}

Sarto, Gianmarco ^{[1
]}

Petrozza, Vincenzo ^{[1
]}

Frati, Giacomo ^{[1
,2
]}

Sciarretta, Sebastiano ^{[1
,2
,3
]}

机构：

[1] Sapienza Univ Rome, Dept Med & Surg Sci & Biotechnol, I-04100 Latina, Italy

[2] IRCCS Neuromed, I-86077 Pozzilli, Italy

[3] Sapienza Univ Rome, Ist Pasteur Italia, Fdn Cenci Bolognetti, I-04100 Latina, Italy

来源：

CELLS | 2022年 / 11卷 / 07期

关键词：

ischemic injury; myocardial ischemia; infarction; ischemia; reperfusion (I; R); molecular; mechanisms; pathway; translational; state of the art; MITOCHONDRIAL PERMEABILITY TRANSITION; ACTIVATED PROTEIN-KINASE; MESENCHYMAL STEM-CELLS; AMELIORATES CARDIAC DYSFUNCTION; NECROSIS-FACTOR-ALPHA; REPERFUSION INJURY; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; NADPH OXIDASE; MURINE MODEL;

D O I：

10.3390/cells11071165

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiovascular disease is the leading cause of death in western countries. Among cardiovascular diseases, myocardial infarction represents a life-threatening condition predisposing to the development of heart failure. In recent decades, much effort has been invested in studying the molecular mechanisms underlying the development and progression of ischemia/reperfusion (I/R) injury and post-ischemic cardiac remodeling. These mechanisms include metabolic alterations, ROS overproduction, inflammation, autophagy deregulation and mitochondrial dysfunction. This review article discusses the most recent evidence regarding the molecular basis of myocardial ischemic injury and the new potential therapeutic interventions for boosting cardioprotection and attenuating cardiac remodeling.

引用

页数：35

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