The risk of bradykinin B2 receptor-58T/C gene polymorphism on hypertension: a meta-analysis

被引:0
作者
Luo, Kaiping [1 ]
Kang, Wenling [1 ]
Xu, Gaosi [2 ]
机构
[1] Nanchang Univ, Med Ctr, Grad Sch, Nanchang 330006, Peoples R China
[2] Nanchang Univ, Dept Nephrol, Affiliated Hosp 2, 1 Minde Rd, Nanchang 330006, Peoples R China
关键词
Bradykinin B2 receptor; polymorphism; hypertension; meta-analysis; PROMOTER POLYMORPHISM; ASSOCIATION;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: The risk of bradykinin B2 receptor (BDKRB2)-58T/C gene polymorphism on hypertension remains controversial. Materials and methods: The Cochrane Library, Chinese Biomedical Database, EBSCO, Embase, ISI, MEDLINE, and PubMed were retrieved, and relevant articles were selected. Results: The significant association between BDKRB2-58T/C gene polymorphism and risk of hypertension were found under C-allele comparison [odds ratio (OR): 1.22, 95% confidential intervals (CI): 1.05-1.42, recessive model (OR: 1.32, 95% CI: 1.07-1.64), dominant model (OR: 0.74, 95% CI: 0.58-0.94), homozygote model (OR: 1.66, 95% CI: 1.11-2.47) and heterozygote model (OR: 1.23, 95% CI: 1.06-1.43). The magnitude of the association between the BDKRB2-58T/C gene polymorphism and risk of hypertension was substantiated in Asians under C-allele comparison (OR: 1.24, 95% CI: 1.04-1.49), recessive model (OR: 1.39, 95% CI: 1.04-1.86), dominant model (OR: 0.72, 95% CI: 0.56-0.93), homozygote model (OR: 1.78, 95% CI: 1.09-2.90) and heterozygote model (OR: 1.26, 95% CI: 1.07-1.49). No publication bias was found in the meta-analysis. Conclusions: The meta-analysis suggested -58C allele and -58CC genotype increase the risk of hypertension. Inversely, -58TT genotype decreases the risk of hypertension.
引用
收藏
页码:19917 / 19927
页数:11
相关论文
共 27 条
[1]  
[Anonymous], CHINESE J GERONTOLOG
[2]  
[Anonymous], J MED MOL BIOL
[3]  
[Anonymous], ASS GENETIC POLYMORP
[4]  
[Anonymous], CHINESE J GERONTOLOG
[5]  
[Anonymous], ACTA ACAD MED MILITA
[6]   The genetic factor in acute myocardial infarction with hypertension [J].
Aoki, S ;
Mukae, S ;
Itoh, S ;
Sato, R ;
Nishio, K ;
Iwata, T ;
Katagiri, T .
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 2001, 65 (07) :621-626
[7]   Association and Interaction of -58C> T and ±9 bp Polymorphisms of BDKRB2 Gene Causing Susceptibility to Essential Hypertension [J].
Bhupatiraju, Charita ;
Patkar, Sushma ;
Pandharpurkar, Deepak ;
Joshi, Sindhu ;
Tirunilai, Padma .
CLINICAL AND EXPERIMENTAL HYPERTENSION, 2012, 34 (03) :230-235
[8]   IDENTIFICATION OF POLYMORPHIC SITES OF THE HUMAN BRADYKININ B-2 RECEPTOR GENE [J].
BRAUN, A ;
KAMMERER, S ;
BOHME, E ;
MULLER, B ;
ROSCHER, AA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 211 (01) :234-240
[9]   Sequence variation of bradykinin receptors B1 and B2 and association with hypertension [J].
Cui, J ;
Melista, E ;
Chazaro, I ;
Zhang, YJ ;
Zhou, XF ;
Manolis, AJ ;
Baldwin, CT ;
DeStefano, AL ;
Gavras, H .
JOURNAL OF HYPERTENSION, 2005, 23 (01) :55-62
[10]   METAANALYSIS IN CLINICAL-TRIALS [J].
DERSIMONIAN, R ;
LAIRD, N .
CONTROLLED CLINICAL TRIALS, 1986, 7 (03) :177-188