Applications of Synthetic Organic Tetrasulfides as H2S Donors

被引：69
|
作者：
Cerda, Matthew M. [1 ]
Hammers, Matthew D. [1 ]
Earp, Mary S. [1 ]
Zakharov, Lev N. [1 ]
Pluth, Michael D. [1 ]
机构：
[1] Univ Oregon, Inst Mol Biol, Inst Mat Sci, Dept Chem & Biochem, Eugene, OR 97403 USA
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 09期
基金：
美国国家科学基金会;
关键词：
HYDROGEN-SULFIDE DONORS; N-ACETYLCYSTEINE; POLYSULFIDES; TRISULFIDE; GENERATION; DISULFIDE; CHEMISTRY; BIOLOGY;
D O I：
10.1021/acs.orglett.7b00858
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In an effort to expand the availability of simple polysulfides for H2S donation, we report here the synthesis and H2S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H2S in a first-order dependence on, reduced glutathione (GSH) and release more H2S than the commonly used trisulfide DATS.
引用
收藏
页码：2314 / 2317
页数：4
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