Synthesis, Structure and in vitro Antitumor Activity of a Multinuclear Diorganotin(IV) Complex [(n-Bu)4Sn2{2,5-F2C6H3C(=O)NHO}2{2,5-F2C6H3C(=NO)O}]2

被引：4
作者：
Shang Xianmei [1 ]
Meng Xianggao [3 ]
Li Qingshan [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Sch Pharm, Wuhan 430030, Hubei, Peoples R China
[2] Shanxi Med Univ, Sch Pharmaceut Sci, Taiyuan 030001, Shanxi, Peoples R China
[3] Cent China Normal Univ, Dept Chem, Wuhan 430079, Hubei, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2010年 / 28卷 / 02期
基金：
中国国家自然科学基金;
关键词：
multinuclear dibutyltin(IV); crystal structure; antitumor activity; HYDROXAMIC ACID INHIBITORS; 5-LIPOXYGENASE;
D O I：
10.1002/cjoc.201090068
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new multinuclear dibutyltin(IV) complex [(n-Bu)(4)Sn-2{2,5-F2C6H3C(=O)NHO}(2){2,5-F2C6H3C(=NO)O}](2) 1, was synthesized and structurally characterized by melting point measurement, elemental analysis, FT-IR, H-1, C-13, Sn-119 NMR spectroscopies, and X-ray diffraction analysis. The complex exhibited in vitro antitumor activity against a murine sarcoma carcinoma cell line (S-180), which was higher than that of 5-fluorouracil (5-Fu), currently used clinically as an antitumor agent.
引用
收藏
页码：289 / 293
页数：5
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