Advances in the epigenetics of fibroblast biology and fibrotic diseases

被引：8

作者：

Ulukan, Burge ^{[1
]}

Ozkaya, Yasemin Sila ^{[1
]}

Zeybel, Mujdat ^{[1
]}

机构：

[1] Koc Univ, Sch Med, Dept Gastroenterol & Hepatol, Istanbul, Turkey

来源：

CURRENT OPINION IN PHARMACOLOGY | 2019年 / 49卷

关键词：

STELLATE CELL ACTIVATION; DNA-METHYLATION; FIBROSIS PROGRESSION; PULMONARY-FIBROSIS; LIVER-DISEASE; PROMOTES; TRANSDIFFERENTIATION; INHIBITION; RASAL1;

D O I：

10.1016/j.coph.2019.10.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Fibroblasts have a central role in tissue fibrosis and fibrotic diseases. Fibroblast activation is regulated by several mechanisms including epigenetic modifications; histone modifications, DNA methylation and non-coding RNAs. Although research has significantly contributed to our basic understanding of fibrotic diseases over the last decade, cooperative activity of epigenetic mechanisms demonstrates the complexity of fibrogenesis. This review will summarise the latest epigenetic advances in fibroproliferative diseases. Current studies investigating biological implications of epigenetic modifiers, inhibitors of DNA methylation/histone modifying enzymes are promising. Given that ncRNA-based or CRISPR-based epigenetic-editing have shown therapeutic potential in the preclinical models; we consider epigenetic mechanisms represent a potential tool with clinical utility.

引用

页码：102 / 109

页数：8

共 48 条

[1]

Allen RJ, 2017, LANCET RESP MED, V5, P869, DOI [10.1016/s2213-2600(17)30387-9, 10.1016/S2213-2600(17)30387-9]

[2] Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity [J].

Angermueller, Christof ;

Clark, Stephen J. ;

Lee, Heather J. ;

Macaulay, Iain C. ;

Teng, Mabel J. ;

Hu, Tim Xiaoming ;

Krueger, Felix ;

Smallwood, Sebastien A. ;

Ponting, Chris P. ;

Voet, Thierry ;

Kelsey, Gavin ;

Stegle, Oliver ;

Reik, Wolf .

NATURE METHODS, 2016, 13 (03) :229-+

[3] Methylation determines fibroblast activation and fibrogenesis in the kidney [J].

Bechtel, Wibke ;

McGoohan, Scott ;

Zeisberg, Elisabeth M. ;

Mueller, Gerhard A. ;

Kalbacher, Hubert ;

Salant, David J. ;

Mueller, Claudia A. ;

Kalluri, Raghu ;

Zeisberg, Michael .

NATURE MEDICINE, 2010, 16 (05) :544-U75

[4] The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis [J].

Bergmann, Christina ;

Brandt, Amelie ;

Merlevede, Benita ;

Hallenberger, Ludwig ;

Dees, Clara ;

Wohlfahrt, Thomas ;

Poetter, Sebastian ;

Zhang, Yun ;

Chen, Chih-Wei ;

Mallano, Tatiana ;

Liang, Ruifang ;

Kagwiria, Rosebeth ;

Kreuter, Alexander ;

Pantelaki, Ioanna ;

Bozec, Aline ;

Abraham, David ;

Rieker, Ralf ;

Ramming, Andreas ;

Distler, Oliver ;

Schett, Georg ;

Distler, Joerg H. W. .

ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (01) :150-+

[5] DNA methylation detection: recent developments in bisulfite free electrochemical and optical approaches [J].

Bhattacharjee, Ripon ;

Moriam, Sofia ;

Umer, Muhammad ;

Nam-Trung Nguyen ;

Shiddiky, Muhammad J. A. .

ANALYST, 2018, 143 (20) :4802-4818

[6] MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis [J].

Caviglia, Jorge Matias ;

Yan, Jun ;

Jang, Myoung-Kuk ;

Gwak, Geum-Youn ;

Affo, Silvia ;

Yu, Lexing ;

Olinga, Peter ;

Friedman, Richard A. ;

Chen, Xin ;

Schwabe, Robert F. .

HEPATOLOGY, 2018, 67 (06) :2414-2429

[7] Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis [J].

Coward, William R. ;

Brand, Oliver J. ;

Pasini, Alice ;

Jenkins, Gisli ;

Knox, Alan J. ;

Pang, Linhua .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2018, 58 (04) :449-460

[8] Controlling CRISPR-Cas9 Gene Editing [J].

Dowdy, Steven F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (03) :289-290

[9] Genetic architecture of human fibrotic diseases: disease risk and disease progression [J].

Gardet, Agnes ;

Zheng, Timothy S. ;

Viney, Joanne L. .

FRONTIERS IN PHARMACOLOGY, 2013, 4

[10] Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease [J].

Hardy, Timothy ;

Zeybel, Mujdat ;

Day, Christopher P. ;

Dipper, Christian ;

Masson, Steven ;

McPherson, Stuart ;

Henderson, Elsbeth ;

Tiniakos, Dina ;

White, Steve ;

French, Jeremy ;

Mann, Derek A. ;

Anstee, Quentin M. ;

Mann, Jelena .

GUT, 2017, 66 (07) :1321-1328

← 1 2 3 4 5 →