Toll-Like Receptor Signaling in the Establishment and Function of the Immune System

被引：87

作者：

Aluri, Jahnavi ^{[1
]}

Cooper, Megan A. ^{[1
]}

Schuettpelz, Laura G. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

来源：

CELLS | 2021年 / 10卷 / 06期

基金：

美国国家卫生研究院;

关键词：

TLR; immune system; inborn errors of immunity; ANHIDROTIC ECTODERMAL DYSPLASIA; NF-KAPPA-B; HERPES-SIMPLEX ENCEPHALITIS; REGULATES HEMATOPOIETIC STEM; DOUBLE-STRANDED-RNA; VIRUS ENCEPHALITIS; TLR3; DEFICIENCY; ALPHA MUTATION; BACTERIAL-INFECTIONS; OTHERWISE REDUNDANT;

D O I：

10.3390/cells10061374

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Toll-like receptors (TLRs) are pattern recognition receptors that play a central role in the development and function of the immune system. TLR signaling promotes the earliest emergence of hematopoietic cells during development, and thereafter influences the fate and function of both primitive and effector immune cell types. Aberrant TLR signaling is associated with hematopoietic and immune system dysfunction, and both loss- and gain-of- function variants in TLR signaling-associated genes have been linked to specific infection susceptibilities and immune defects. Herein, we will review the role of TLR signaling in immune system development and the growing number of heritable defects in TLR signaling that lead to inborn errors of immunity.

引用

页数：17

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