QseA and Gr1R/Gr1A regulation of the locus of enterocyte effacement genes in enterohemorrhagic Escherichia coli

被引:50
作者
Russell, Regan M. [1 ]
Sharp, Faith C. [1 ]
Rasko, David A. [1 ]
Sperandio, Vanessa [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA
关键词
D O I
10.1128/JB.00553-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagic Escherichia coli (EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activate LEE2 transcription in a Ler-independent fashion, whereas transcription of grlRA is activated by QseA in both Ler-dependent and -independent manners.
引用
收藏
页码:5387 / 5392
页数:6
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