Sporadic Creutzfeldt-Jakob disease with glial PrPRes nuclear and perinuclear immunoreactivity

被引：2

作者：

Fernandez-Vega, Ivan ^{[1
,2
]}

Diaz-Lucena, Daniela ^{[3
,4
]}

Azkune Calle, Itxaso ^{[7
]}

Geijo, Maria ^{[8
]}

Juste, Ramon A. ^{[8
]}

Llorens, Franc ^{[3
,4
]}

Vicente Etxenausia, Ikerne ^{[2
]}

Santos-Juanes, Jorge ^{[9
]}

Zarranz Imirizaldu, Juan Jose ^{[10
]}

Ferrer, Isidro ^{[3
,4
,5
,6
]}

机构：

[1] Hosp Univ Araba, Pathol Dept, Vitoria, Spain

[2] Brain Bank Hosp Univ Araba, Biobanco Vasco Invest eHun O, Vitoria, Spain

[3] Univ Barcelona, Biomed Res Inst Bellvitge IDIBELL, Lhospitalet De Llobregat, Spain

[4] Univ Barcelona, Biomed Network Res Ctr Neurodegenerat Dis CIBERNE, Lhospitalet De Llobregat, Spain

[5] Univ Barcelona, Dept Pathol & Expt Therapeut, C Feixa Llarga Sn, Lhospitalet De Llobregat 08907, Spain

[6] Bellvitge Univ Hosp, Serv Pathol Anat, Lhospitalet De Llobregat, Spain

[7] Hosp Galdakao Usansolo, Neurol Dept, Galdakao, Spain

[8] NEIKER Tecnalia, Dept Anim Hlth, Derio, Spain

[9] Hosp Univ Cent Asturias, Pathol Dept, Oviedo, Spain

[10] Hosp Univ Cruces, Neurol Dept, Baracaldo, Spain

来源：

NEUROPATHOLOGY | 2018年 / 38卷 / 05期

关键词：

astrocytes; Creutzfeldt-Jakob disease; oligodendrocytes; prion; PRION PROTEIN; CLASSIFICATION; IDENTIFICATION; LOCALIZATION; SUBTYPES; SCRAPIE; BRAIN; CELLS;

D O I：

10.1111/neup.12505

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Proteinase K-resistant prion protein (PrPRes) nuclear and perinuclear immunoreactivity in oligodendrocytes of the frontal cortex is found in one case of otherwise typical sporadic Creutzfeldt-Jakob disease (sCJD) type VV2a. The PrP nature of the inclusions is validated with several anti-PrP antibodies directed to amino acids 130-160 (12F10), 109-112 (3F4), 97-102 (8G8) and the octarepeat region (amino acids 59-89: SAF32). Cellular identification and subcellular localization were evaluated with double- and triple-labeling immunofluorescence and confocal microscopy using antibodies against PrP, glial markers, and histone H3. Based on review of the literature and our own experience, this is a very odd situation that deserves further validation in other cases.

引用

页码：561 / 567

页数：7

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