Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile

被引：15
作者：
Wang, Bin [1 ]
Chen, Liang [1 ]
Chang, Hao-Teng [2 ,3 ]
机构：
[1] Wenzhou Med Univ, Affiliated Dongyang Hosp, Dept Hepatobiliary Surg, Dongyang 322100, Zhejiang, Peoples R China
[2] China Med Univ, Grad Inst Basic Med Sci, Coll Med, Taichung 40402, Taiwan
[3] Asia Univ, Dept Comp Sci & Informat Engn, Taichung 41354, Taiwan
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 06期
关键词：
bile; biomarker; cholangiocarcinoma; serum; TOTAL SIALIC-ACID; CARBOHYDRATE ANTIGEN 19-9; PYRUVATE-KINASE M2; INTRAHEPATIC CHOLANGIOCARCINOMA; GROWTH-FACTOR; DETECTING CHOLANGIOCARCINOMA; MATRIX METALLOPROTEINASE-7; CYTOKERATIN-19; FRAGMENT; RHEUMATOID-ARTHRITIS; EXPRESSION;
D O I：
10.2217/bmm-2015-0062
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cholangiocarcinoma (CCA) is a devastating malignancy that is difficult to treat because of its insensitivity to conventional therapies and the inability to detect early tumor formation. Novel molecular techniques have enabled the use of serum and bile markers for CCA diagnosis and prognosis. Herein, we summarize the principal characteristics of serum and bile markers of CCA. Biomarkers such as interleukin-6, matrix metalloproteinases, serotonin (5-hydroxytryptamine) and bile acids have shown promise for improving CCA diagnosis. Several markers such as CYFRA 21-1, MK-1 and C-reactive protein were recently shown to be effective for CCA prognosis.
引用
收藏
页码：613 / 619
页数：7
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