A nano-carbon electrode optimized for adsorptive stripping voltammetry: Application to detection of the stimulant selegiline in authentic saliva

被引：35
作者：
dos Santos, Wallans T. P. [1 ,2 ]
Amin, Hatem M. A. [2 ]
Compton, Richard G. [2 ]
机构：
[1] Univ Fed Vales Jequitinhonha & Mucuri, Dept Pharm, Campus JK, BR-39100000 Diamantina, MG, Brazil
[2] Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, South Parks Rd, Oxford OX1 3QZ, England
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2019年 / 279卷
关键词：
Adsorptive stripping voltammetry; Carbon Black; Doping control; Saliva; Selegiline; ORAL FLUID; CYCLIC VOLTAMMETRY; NANOTUBES; PLASMA; PHARMACOKINETICS; VOLUNTEERS; URINE; DRUGS;
D O I：
10.1016/j.snb.2018.10.037
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A multilayer Carbon Black (CB) modified Glassy Carbon Electrode (GCE) is proposed, developed and optimized for Adsorptive Stripping Voltammetry (AdSV). The thick (up to 1000 monolayers) multilayer CB modification offers a significant enhancement in sensitivity for AdSV but not diffusive voltammetry. The detection of the stimulant selegiline, which is a prohibited drug for athletes in sports competitions, is used as model for application of the proposed electrochemical method in saliva samples. The analytical performance of the CB-GCE for detection of seligeline in authentic saliva samples revealed a limit of detection of 0.12 mu mol L-1 which is sufficiently low to allow a possible application of this fast method in the doping control of this drug.
引用
收藏
页码：433 / 439
页数：7
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