Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

被引：10
|
作者：
Matsuura, Hiroki [1 ]
Kimoto, Sohei [2 ]
Harada, Izumi [1 ]
Naemura, Satoshi [1 ]
Yamamuro, Kazuhiko [2 ]
Kishimoto, Toshifumi [2 ]
机构：
[1] Tenri Hosp, Dept Psychiat, Tenri, Nara 632, Japan
[2] Nara Med Univ, Dept Psychiat, Sch Med, 840 Shijo Cho, Kashihara, Nara 6348521, Japan
来源：
BMC PSYCHIATRY | 2016年 / 16卷
关键词：
Schizoaffective disorder; Schizophrenia; Paliperidone extended-release; Neutropenia; Leukopenia; Lithium carbonate; Valproic acid; CLOZAPINE-INDUCED NEUTROPENIA;
D O I：
10.1186/s12888-016-0874-x
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Background: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. Case presentation: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. Conclusion: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.
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页数：3
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