Effects of Dietary Lysine on Growth Performance, Serum Concentrations of Insulin-Like Growth Factor-I (IGF-I) and IGF-I mRNA Expression in Growing Rabbits

The effects of dietary lysine on production performance, serum concentrations of metabolites, growth hormone (OH), insulin-like growth factor-I (IGF-I) and IGF-I mRNA expression in growing rabbits were examined One hundred weaned New Zealand rabbits were allocated to individual cages and randomly offered a diet containing 5 5 (L1), 6 5 (L2), 7.5 (L3), 8.5 (L4), or 9 5 g (L5) lysine per kg diet. The results showed that the average daily gain (ADO) of the rabbits from L3, L4 or L5 was higher than those from L1 or L2 (P < 0.05) The feed gain ratio (FIG) in the rabbits from L4 or L5 was lower than those from L1 or L2 (P<0.05) Dietary lysine did not affect serum concentrations of total protein (TP), glucose, insulin (INS), and growth hormone (OH) (P>0 05). The quadratic effects of lysine on the serum urea nitrogen (SUN) concentration was detected (P=0 035) Scrum IGF-I concentrations had a trend to increase quadratically with the increasing dietary lysine (P=0.07) A significant correlation was found between serum IGF-I concentrations (x, ng mL(-1)) and ADO (y, g kg(-1)): y=-0 017x(2) + 1 984x + 20 87 (R-2=0 8982, P=0.003). The relative abundance of hepatic and muscular IGF-I mRNA tended to increase with increasing dietary lysine levels (P=0.053 and 0.082, respectively). Providing the diets mainly consisted of corn, wheat bran and peanut vine, the most appropriate dietary lysine level for growing meat rabbits from weaning to 70 d old was found to be 8.5 g kg(-1), and IGF-I may be an important factor controlling growth of weaned rabbits