The role of liposomes in analytical processes

被引：99
作者：
Gómez-Hens, A [1 ]
Fernández-Romero, JM [1 ]
机构：
[1] Univ Cordoba, Fac Med, Dept Analyt Chem, E-14071 Cordoba, Spain
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2005年 / 24卷 / 01期
关键词：
capillary electrophoresis; chromatography; immunoassays; liposomes; sensors;
D O I：
10.1016/j.trac.2004.07.017
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We present a general survey of the preparation, the behaviour and the characterization of liposomes, and their versatility as analytical tools. Advances on the design of artificial liposomes have allowed manipulation of their features (size, lamellarity, resistance, fusion capability and encapsulation efficiency), which have given rise to a wide range of procedures to encapsulate or internalise a variety of reagents. These approaches have been used to study solute-membrane interactions and to improve sensitivity and/or selectivity in different analytical methods. We discuss the advantages and the limitations of the most recent applications of liposomes in chromatography, capillary electrophoresis, immunoassays, sensors and microfluidic systems. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9 / 19
页数：11
相关论文
共 102 条
[11]   Immobilized liposome and biomembrane partitioning chromatography of drugs for prediction of drug transport [J].
Beigi, F ;
Gottschalk, I ;
Hägglund, CL ;
Haneskog, L ;
Brekkan, E ;
Zhang, YX ;
Österberg, T ;
Lundahl, P .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 164 (1-2) :129-137
[12]   Effects of ions and detergents in drug partition chromatography on liposomes [J].
Boija, E ;
Lundquist, A ;
Pla, JJM ;
Engvall, C ;
Lundahl, P .
JOURNAL OF CHROMATOGRAPHY A, 2004, 1030 (1-2) :273-278
[13]   A novel strategy for the preparation of liposomes: rapid solvent exchange [J].
Buboltz, JT ;
Feigenson, GW .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1999, 1417 (02) :232-245
[14]   Characterization of solvation properties of lipid bilayer membranes in liposome electrokinetic chromatography [J].
Burns, ST ;
Agbodjan, AA ;
Khaledi, MG .
JOURNAL OF CHROMATOGRAPHY A, 2002, 973 (1-2) :167-176
[15]   Rapid determination of liposome-water partition coefficients (Klw) using liposome electrokinetic chromatography (LEKC) [J].
Burns, ST ;
Khaledi, MG .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (07) :1601-1612
[16]   Neuronal biosensors using liposomal delivery of local anesthetics [J].
Coon, DR ;
Ogunseitan, AB ;
Rechnitz, GA .
ANALYTICAL CHEMISTRY, 1997, 69 (20) :4120-4125
[17]   A vesicle capture sensor chip for kinetic analysis of interactions with membrane-bound receptors [J].
Cooper, MA ;
Hansson, A ;
Löfås, S ;
Williams, DH .
ANALYTICAL BIOCHEMISTRY, 2000, 277 (02) :196-205
[18]   Phospholipid bilayer coatings for the separation of proteins in capillary electrophoresis [J].
Cunliffe, JM ;
Baryla, NE ;
Lucy, CA .
ANALYTICAL CHEMISTRY, 2002, 74 (04) :776-783
[19]  
de Oliveira MC, 2001, STP PHARMA SCI, V11, P103
[20]  
Desormeaux A, 1998, J DRUG TARGET, V6, P1
12345678910