An EMT-related gene signature for the prognosis of human bladder cancer

被引:161
作者
Cao, Rui [1 ]
Yuan, Lushun [2 ]
Ma, Bo [3 ]
Wang, Gang [4 ]
Qiu, Wei [1 ]
Tian, Ye [1 ]
机构
[1] Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Yong Rd 95, Beijing 100050, Peoples R China
[2] Leiden Univ, Med Ctr, Dept Internal Med, Div Nephrol, Leiden, Netherlands
[3] Capital Med Univ, Beijing Shijitan Hosp, Dept Stomatol, Beijing, Peoples R China
[4] Wuhan Univ, Zhongnan Hosp, Dept Biol Repositories, Wuhan, Hubei, Peoples R China
关键词
bladder cancer; Cox; EMT; GEO; LASSO; signature; TCGA; EPITHELIAL-MESENCHYMAL PLASTICITY; INVASIVE UROTHELIAL CARCINOMA; RADICAL CYSTECTOMY; URINARY-BLADDER; EAU GUIDELINES; PROGRESSION; MORTALITY; SURVIVAL; FEATURES; RATES;
D O I
10.1111/jcmm.14767
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The transition from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) is detrimental to bladder cancer (BLCA) patients. Here, we aimed to study the underlying mechanism of the subtype transition. Gene set variation analysis (GSVA) revealed the epithelial-mesenchymal transition (EMT) signalling pathway with the most positive correlation in this transition. Then, we built a LASSO Cox regression model of an EMT-related gene signature in BLCA. The patients with high risk scores had significantly worse overall survival (OS) and disease-free survival (DFS) than those with low risk scores. The EMT-related gene signature also performed favourably in the accuracy of prognosis and in the subtype survival analysis. Univariate and multivariate Cox regression analyses demonstrated that the EMT-related gene signature, pathological N stage and age were independent prognostic factors for predicting survival in BLCA patients. Furthermore, the predictive nomogram model was able to effectively predict the outcome of BLCA patients by appropriately stratifying the risk score. In conclusion, we developed a novel EMT-related gene signature that has tumour-promoting effects, acts as a negative independent prognostic factor and might facilitate personalized counselling and treatment in BLCA.
引用
收藏
页码:605 / 617
页数:13
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