Indiplon: the development of a novel therapy for the treatment of sleep onset and sleep maintenance insomnia

被引：7
作者：
Lankford, A.
Ancoli-Israel, S.
机构：
[1] Sleep Disorders Ctr Georgia, Atlanta, GA USA
[2] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
来源：
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2007年 / 61卷 / 06期
关键词：
D O I：
10.1111/j.1742-1241.2007.01322.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Indiplon is a novel non-benzodiazepine sedative-hypnotic that modulates the GABA(A) receptor complex. It appears to be more selective for the alpha 1-receptor subunit, associated with sedation, than other hypnotics. Two different formulations of indiplon have been developed: an immediate release (IR) version targeting sleep onset insomnia and a modified release (MR) version addressing sleep maintenance insomnia. Early results from clinical trials indicate that both formulations are well tolerated and effective at improving both objective and subjective measures of sleep. As of May 2006 indiplon-IR has been provisionally approved for use in the US market and discussions are continuing with the FDA regarding the MR formulation.
引用
收藏
页码：1037 / 1045
页数：9
相关论文
共 50 条
[41]   Sleep maintenance insomnia and nasal flow limitation; A randomized treatment study [J].
Lee, J ;
Guilleminault, C .
SLEEP, 2005, 28 :A227-A227
[42]   THE EFFECTS OF PRE-SLEEP STRESS ON SLEEP-ONSET INSOMNIA [J].
HAYNES, SN ;
ADAMS, A ;
FRANZEN, M .
JOURNAL OF ABNORMAL PSYCHOLOGY, 1981, 90 (06) :601-606
[43]   ANALYSIS OF STIMULUS-CONTROL TREATMENT OF SLEEP-ONSET INSOMNIA [J].
ZWART, CA ;
LISMAN, SA .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1979, 47 (01) :113-118
[44]   A new sublingual formulation of zolpidem for the treatment of sleep-onset insomnia [J].
Staner, Luc ;
Danjou, Philippe ;
Luthringer, Remy .
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2012, 12 (02) :141-153
[45]   PRE-SLEEP COGNITIVE INTRUSIONS AND TREATMENT OF ONSET-INSOMNIA [J].
SANAVIO, E .
BEHAVIOUR RESEARCH AND THERAPY, 1988, 26 (06) :451-459
[46]   SELF-ADMINISTERED TREATMENT OF SLEEP ONSET INSOMNIA AND THE IMPORTANCE OF AGE [J].
ALPERSON, J ;
BIGLAN, A .
BEHAVIOR THERAPY, 1979, 10 (03) :347-356
[47]   TREATMENT OF SLEEP-MAINTENANCE INSOMNIA IN OLDER ADULTS - SLEEP PERIOD REDUCTION, SLEEP EDUCATION, AND MODIFIED STIMULUS-CONTROL [J].
HOELSCHER, TJ ;
EDINGER, JD .
PSYCHOLOGY AND AGING, 1988, 3 (03) :258-263
[48]   TREATMENT OF SLEEP ONSET INSOMNIA BY PARADOXICAL INSTRUCTION - MULTIPLE BASELINE DESIGN [J].
RELINGER, H ;
BORNSTEIN, PH .
BEHAVIOR MODIFICATION, 1979, 3 (02) :203-222
[49]   SLEEP CLINIC TREATMENT OF INSOMNIA [J].
REGESTEIN, QR ;
REICH, P .
AMERICAN JOURNAL OF PSYCHIATRY, 1982, 139 (10) :1379-1379
[50]   HUMAN SLEEP AND TREATMENT OF INSOMNIA [J].
COQUEREL, A ;
SAMSONDOLLFUS, D .
GAZETTE MEDICALE, 1990, 97 (04) :61-68
12345