Evaluation of Gellan Gum/Glycol Chitosan Bioabsorbable Membrane for Guided Bone Regeneration

Bioabsorbable membrane was prepared using gellan gum (GEL)-glycol chitosan (GC) with phosphate-buffered saline (PBS) as a crosslinker for guided bone regeneration (GBR). The GEL/GC membrane was characterized by Fourier transform infrared (FTIR), degradation, contact angle, tensile strength and cell viability. The result showed that by increasing the GC content in GEL membrane, the degradable and mechanical properties were decreased. New bone was observed through micro-CT and histological evaluation of forming a defect in rat calvarial and fixing the membrane. The amount of newbone regeneration was significantly greater in GEL/GC group than the control. The GEL/GC membrane blocked the soft tissue and has effects on the new bone formation.