Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers

被引：7

作者：

Aslam, Adil S. ^{[1
]}

Fuwad, Ahmed ^{[4
]}

Ryu, Hyunil ^{[2
]}

Selvaraj, Baskar ^{[3
]}

Song, Jae-Won ^{[1
]}

Kim, Dae Won ^{[5
]}

Kim, Sun Min ^{[4
]}

Lee, Jae Wook ^{[3
]}

Jeon, Tae-Joon ^{[2
]}

Cho, Dong-Gyu ^{[1
]}

机构：

[1] Inha Univ, Dept Chem & Chem Engn, Incheon 22212, South Korea

[2] Inha Univ, Dept Biol Engn, Incheon 22212, South Korea

[3] Korea Inst Sci & Technol, Nat Prod Res Ctr, Gangneung Inst, Kangnung 25451, South Korea

[4] Inha Univ, Dept Mech Engn, Incheon 22212, South Korea

[5] Gangneung Wonju Natl Univ, Coll Dent, Res Inst Oral Sci, Dept Biochem & Mol Biol, Kangnung 25457, South Korea

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 19期

基金：

新加坡国家研究基金会;

关键词：

CELL-DEATH; APOPTOSIS; BINDING; CALCIUM;

D O I：

10.1021/acs.orglett.9b02823

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP.

引用

页码：7828 / 7832

页数：5

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