Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus

被引：20

作者：

Yurchenko, Anton N. ^{[1
]}

Phan Thi Hoai Trinh ^{[2
]}

Girich , Elena V. ^{[1
]}

Smetanina, Olga F. ^{[1
]}

Rasin, Anton B. ^{[1
]}

Popov, Roman S. ^{[1
]}

Dyshlovoy, Sergey A. ^{[1
,3
,4
,5
]}

von Amsberg, Gunhild ^{[4
,5
]}

Menchinskaya, Ekaterina S. ^{[1
]}

Tran Thi Thanh Van ^{[2
]}

Afiyatullov, Shamil Sh. ^{[1
]}

机构：

[1] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Prospect 100 Letiya Vladivostoka,159, Vladivostok 690022, Russia

[2] Vietnam Acad Sci & Technol, Nhatrang Inst Technol Res & Applicat, Dept Marine Biotechnol, Nha Trang 650000, Vietnam

[3] Far Eastern Fed Univ, Sch Nat Sci, Sukhanova St 8, Vladivostok 690000, Russia

[4] Univ Med Ctr Hamburg Eppendorf, Lab Expt Oncol, Dept Oncol Hematol & Bone Marrow Transplantat, Sect Pneumol,Hubertus Wald Tumorzentrum, D-20246 Hamburg, Germany

[5] Univ Hosp Hamburg Eppendorf, Martini Klin, Prostate Canc Ctr, D-20246 Hamburg, Germany

来源：

MARINE DRUGS | 2019年 / 17卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

marine-derived fungi; secondary metabolites; polyketides; drimanes; meroterpenoids; cytotoxicity; NITROBENZOYL SESQUITERPENOIDS; POLYKETIDES; DERIVATIVES; RESISTANCE;

D O I：

10.3390/md17100579

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1-10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher's method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.

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页数：12

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