Long-term mortality rate for cardiovascular disease in 656 chronic myeloid leukaemia patients treated with second- and third-generation tyrosine kinase inhibitors

被引：21

作者：

Caocci, Giovanni ^{[1
]}

Mulas, Olga ^{[1
]}

Annunziata, Mario ^{[2
]}

Luciano, Luigiana ^{[3
]}

Abruzzese, Elisabetta ^{[4
]}

Bonifacio, Massimiliano ^{[5
]}

Orlandi, Ester Maria ^{[6
]}

Albano, Francesco ^{[7
]}

Galimberti, Sara ^{[8
]}

Iurlo, Alessandra ^{[9
]}

Pregno, Patrizia ^{[10
]}

Sgherza, Nicola ^{[11
]}

Martino, Bruno ^{[12
]}

Binotto, Gianni ^{[13
]}

Castagnetti, Fausto ^{[14
]}

Gozzini, Antonella ^{[15
]}

Bocchia, Monica ^{[16
]}

Fozza, Claudio ^{[17
]}

Stagno, Fabio ^{[18
]}

Simula, Maria Pina ^{[19
]}

De Gregorio, Fiorenza ^{[3
]}

Trawinska, Malgorzata Monika ^{[4
]}

Scaffidi, Luigi ^{[5
]}

Elena, Chiara ^{[6
]}

Attolico, Imma ^{[7
]}

Barate, Claudia ^{[8
]}

Cattaneo, Daniele ^{[9
]}

Pirillo, Francesca ^{[10
]}

Gugliotta, Gabriele ^{[14
]}

Sicuranza, Anna ^{[16
]}

Molica, Matteo ^{[20
]}

La Nasa, Giorgio ^{[1
]}

Foa, Robin ^{[20
]}

Breccia, Massimo ^{[20
]}

机构：

[1] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy

[2] Cardarelli Hosp, Hematol Unit, Naples, Italy

[3] Federico II Univ Naples, Hematol Unit, Naples, Italy

[4] Tor Vergata Univ, Hematol Unit, St Eugenio Hosp, Rome, Italy

[5] Univ Verona, Dept Med, Sect Hematol, Verona, Italy

[6] Fdn IRCCS Policlin S Matteo Univ Hosp, Hematol Unit, Pavia, Italy

[7] Univ Bari, Haematol & Transplants Unit, Bari, Italy

[8] Univ Pisa, Dept Clin & Expt Med, Sect Hematol, Pisa, Italy

[9] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Hematol Unit, Milan, Italy

[10] Azienda Osped Univ Citta Salute & Sci, Hematol Unit, Turin, Italy

[11] Casa Sollievo Sofferenza Hosp, Hematol & Transplant Ctr, San Giovanni Rotondo, Italy

[12] Azienda Osped Bianchi Melacrino Morelli, Hematol Unit, Reggio Di Calabria, Italy

[13] Univ Padua, Hematol Unit, Padua, Italy

[14] Univ Bologna, S Orsola Malpighi Hosp, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[15] Univ Florence, Hematol Unit, AOU Careggi, Florence, Italy

[16] Univ Siena, Azienda Osped Univ Senese, Hematol Unit, Siena, Italy

[17] Univ Sassari, Dept Clin & Expt Med, Sassari, Italy

[18] Ferrarotto Hosp, Hematol Unit, Catania, Italy

[19] Businco Hosp, Hematol & Transplant Ctr, Cagliari, Italy

[20] Sapienza Univ, Dept Cellular Biotechnol & Hematol, Div Hematol, Policlin Umberto 1, Rome, Italy

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2020年 / 301卷

关键词：

Chronic myeloid leuk; a; emia; Cardiovascular toxicity; TKI; Ischemic heart disease; EVENTS;

D O I：

10.1016/j.ijcard.2019.10.036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Limited information is available regarding the rate of long-term cardiovascular (CV) mortality in chronic myeloid leukaemia (CML) patients treated with second- and third-generation tyrosine kinase inhibitors (2nd(G)/3rd(G) TKIs) in the real-life practice. Methods: We identified 656 consecutive CML patients treated with nilotinib, dasatinib, bosutinib and ponatinib. Results: The 15-year CV-mortality free survival was 93 +/- 2.8%. Age >= 65 years (p = 0.005) and a positive history of CV disease (p = 0.04) were significantly associated with a lower CV-mortality free survival. CV disease accounted for 16.5% and 5% of potential years of life lost (PYLL) in male and female patients, respectively. The standard mortality ratio (SMR) following ischemic heart disease (IHD) was 3.9 in males and 3.8 in female patients, meaning an excess of IHD deaths observed, in comparison with the population of control. Conclusion. Prevention strategies based on CV risk factors, in particular in those patients with a previous history of CV disease, should be considered. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：163 / 166

页数：4

共 13 条

[1]

[Anonymous], 2010, HLTH ALL ITALIA

[2]

[Anonymous], WHO Mortality Database: Tables

[3] Life Expectancy of Patients With Chronic Myeloid Leukemia Approaches the Life Expectancy of the General Population [J].

Bower, Hannah ;

Bjorkholm, Magnus ;

Dickman, Paul W. ;

Hoglund, Martin ;

Lambert, Paul C. ;

Andersson, Therese M. -L. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (24) :2851-+

[4] Cardiovascular toxicity in patients with chronic myeloid leukemia treated with second-generation tyrosine kinase inhibitors in the real-life practice: Identification of risk factors and the role of prophylaxis [J].

Caocci, Giovanni ;

Mulas, Olga ;

Annunziata, Mario ;

Luciano, Luigiana ;

Bonifacio, Massimiliano ;

Orlandi, Ester Maria ;

Pregno, Patrizia ;

Galimberti, Sara ;

Rossi, Antonella Russo ;

Abruzzese, Elisabetta ;

Iurlo, Alessandra ;

Martino, Bruno ;

Sgherza, Nicola ;

Binotto, Gianni ;

Castagnetti, Fausto ;

Gozzini, Antonella ;

Fozza, Claudio ;

Bocchia, Monica ;

Sicuranza, Anna ;

Stagno, Fabio ;

Efficace, Fabio ;

Usala, Emilio ;

De Gregorio, Fiorenza ;

Scaffidi, Luigi ;

Elena, Chiara ;

Pirillo, Francesca ;

Barate, Claudia ;

Trawinska, Malgorzata Monika ;

Cattaneo, Daniele ;

Labate, Claudia ;

Gugliotta, Gabriele ;

Molica, Matteo ;

Specchia, Giorgina ;

La Nasa, Giorgio ;

Foa, Robin ;

Breccia, Massimo .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (07) :E159-E161

[5] Recurrent arterial occlusive events in patients with chronic myeloid leukemia treated with second- and third-generation tyrosine kinase inhibitors and role of secondary prevention [J].

Caocci, Giovanni ;

Mulas, Olga ;

Bonifacio, Massimiliano ;

Abruzzese, Elisabetta ;

Galimberti, Sara ;

Orlandi, Ester Maria ;

Iurlo, Alessandra ;

Annunziata, Mario ;

Luciano, Luigiana ;

Castagnetti, Fausto ;

Gozzini, Antonella ;

Stagno, Fabio ;

Binotto, Gianni ;

Pregno, Patrizia ;

Albano, Francesco ;

Martino, Bruno ;

Fozza, Claudio ;

Scaffidi, Luigi ;

Trawinska, Malgorzata Monika ;

Barate, Claudia ;

Elena, Chiara ;

Cattaneo, Daniele ;

Scalzulli, Emilia ;

La Nasa, Giorgio ;

Foa, Robin ;

Breccia, Massimo .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2019, 288 :124-127

[6] Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice [J].

Caocci, Giovanni ;

Mulas, Olga ;

Abruzzese, Elisabetta ;

Iurlo, Alessandra ;

Annunziata, Mario ;

Orlandi, Ester Maria ;

Galimberti, Sara ;

Binotto, Gianni ;

Sgherza, Nicola ;

Luciano, Luigia ;

Martino, Bruno ;

Rossi, Antonella Russo ;

Bonifacio, Massimiliano ;

Fozza, Claudio ;

Trawinska, Malgorzata Monika ;

Cattaneo, Daniele ;

Elena, Chiara ;

Barate, Claudia ;

De Gregorio, Fiorenza ;

Molica, Matteo ;

La Nasa, Giorgio ;

Foa, Robin ;

Breccia, Massimo .

ANNALS OF HEMATOLOGY, 2019, 98 (08) :1885-1890

[7] Arterial occlusive events in chronic myeloid leukemia patients treated with ponatinib in the real-life practice are predicted by the Systematic Coronary Risk Evaluation (SCORE) chart [J].

Caocci, Giovanni ;

Mulas, Olga ;

Abruzzese, Elisabetta ;

Luciano, Luigiana ;

Iurlo, Alessandra ;

Attolico, Immacolata ;

Castagnetti, Fausto ;

Galimberti, Sara ;

Sgherza, Nicola ;

Bonifacio, Massimiliano ;

Annunziata, Mario ;

Gozzini, Antonella ;

Orlandi, Ester Maria ;

Stagno, Fabio ;

Binotto, Gianni ;

Pregno, Patrizia ;

Fozza, Claudio ;

Trawinska, Malgorzata Monika ;

De Gregorio, Fiorenza ;

Cattaneo, Daniele ;

Albano, Francesco ;

Gugliotta, Gabriele ;

Barate, Claudia ;

Scaffidi, Luigi ;

Elena, Chiara ;

Pirillo, Francesca ;

Scalzulli, Emilia ;

La Nasa, Giorgio ;

Foa, Robin ;

Breccia, Massimo .

HEMATOLOGICAL ONCOLOGY, 2019, 37 (03) :296-302

[8] Mortality and Vascular Events Among Elderly Patients With Chronic Myeloid Leukemia: A Retrospective Analysis of Linked SEER-Medicare Data [J].

Lang, Kathleen ;

McGarry, Lisa J. ;

Huang, Huan ;

Dorer, David ;

Kaufman, Elise ;

Knopf, Kevin .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2016, 16 (05) :275-+

[9] Severe adverse events by tyrosine kinase inhibitors decrease survival rates in patients with newly diagnosed chronic-phase chronic myeloid leukemia [J].

Ota, Shuichi ;

Matsukawa, Toshihiro ;

Yamamoto, Satoshi ;

Ito, Shinichi ;

Shindo, Motohiro ;

Sato, Kazuya ;

Kondo, Takeshi ;

Kohda, Kyuhei ;

Sakai, Hajime ;

Mori, Akio ;

Takahashi, Tohru ;

Ikeda, Hiroshi ;

Kuroda, Hiroyuki ;

Haseyama, Yoshihito ;

Yamamoto, Masaki ;

Sarashina, Takeo ;

Yoshida, Makoto ;

Kobayashi, Ryoji ;

Nishio, Mitsufumi ;

Ishihara, Toshimichi ;

Hirayama, Yasuo ;

Kakinoki, Yasutaka ;

Kobayashi, Hajime ;

Fukuhara, Takashi ;

Imamura, Masahiro ;

Kurosawa, Mitsutoshi .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2018, 101 (01) :95-105

[10] Relative survival in patients with chronic-phase chronic myeloid leukaemia in the tyrosine-kinase inhibitor era: analysis of patient data from six prospective clinical trials [J].

Sasaki, Koji ;

Strom, Sara S. ;

O'Brien, Susan ;

Jabbour, Elias ;

Ravandi, Farhad ;

Konopleva, Marina ;

Borthakur, Gautam ;

Pemmaraju, Naveen ;

Daver, Naval ;

Jain, Preetesh ;

Pierce, Sherry ;

Kantarjian, Hagop ;

Cortes, Jorge E. .

LANCET HAEMATOLOGY, 2015, 2 (05) :E186-E193

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