Breaking the affinity ceiling for antibodies and T cell receptors

被引：72
作者：
Foote, J
Eisen, HN
机构：
[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA
[2] Fred Hutchinson Canc Res Ctr, Program Mol Med, Seattle, WA 98109 USA
[3] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
[4] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 20期
关键词：
D O I：
10.1073/pnas.97.20.10679
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：10679 / 10681
页数：3
相关论文
共 28 条
[1]   Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate [J].
Batista, FD ;
Neuberger, MS .
IMMUNITY, 1998, 8 (06) :751-759
[2]   RADIATION CHIMAERA, HOST H-2 ANTIGENS DETERMINE IMMUNE RESPONSIVENESS OF DONOR CYTOTOXIC CELLS [J].
BEVAN, MJ .
NATURE, 1977, 269 (5627) :417-418
[3]   Optimal screening of surface-displayed polypeptide libraries [J].
Boder, ET ;
Wittrup, KD .
BIOTECHNOLOGY PROGRESS, 1998, 14 (01) :55-62
[4]   Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity [J].
Boder, ET ;
Midelfort, KS ;
Wittrup, KD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :10701-10705
[5]   Yeast surface display for screening combinatorial polypeptide libraries [J].
Boder, ET ;
Wittrup, KD .
NATURE BIOTECHNOLOGY, 1997, 15 (06) :553-557
[6]   T cell affinity maturation by selective expansion during infection [J].
Busch, DH ;
Pamer, EG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (04) :701-709
[7]   MATING TYPE-SPECIFIC CELL-CELL RECOGNITION OF SACCHAROMYCES-CEREVISIAE - CELL-WALL ATTACHMENT AND ACTIVE-SITES OF A-AGGLUTININ AND ALPHA-AGGLUTININ [J].
CAPPELLARO, C ;
BALDERMANN, C ;
RACHEL, R ;
TANNER, W .
EMBO JOURNAL, 1994, 13 (20) :4737-4744
[8]   VARIATION IN AFFINITIES OF ANTIBODIES DURING IMMUNE RESPONSE [J].
EISEN, HN ;
SISKIND, GW .
BIOCHEMISTRY, 1964, 3 (07) :996-&
[9]  
FERSHT A, 1977, ENZYME STRUCTURE MEC, P285
[10]  
FOOTE J, 1995, P ANTL ACAD SCI US, V92, P1054
123