A validated UV spectrophotometric method for estimation of nebivolol hydrochloride in bulk and pharmaceutical formulation

被引：17

作者：

Kamila, M. M. ^{[1
]}

Mondal, N. ^{[1
]}

Ghosh, L. K. ^{[1
]}

Gupta, B. K. ^{[1
]}

机构：

[1] Univ Jadavpur, Dept Pharmaceut Technol, Pharmaceut Res Lab 2, Kolkata 700032, W Bengal, India

来源：

PHARMAZIE | 2007年 / 62卷 / 07期

关键词：

D O I：

10.1691/ph.2007.7.6259

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple, sensitive and accurate UV spectrophotometric method was developed for the assay of nebivolol hydrochloride in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 282 nm for nebivolol hydrochloride tablet solution. The linearity range was found to be 5-50 mu g/mL for the drug. It was found that the excipients present in the commercial formulation did not interfere with the method.

引用

页码：486 / 487

页数：2

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