Multivariate Analysis of Risk Factors for Early Loss of Pancreas Grafts Among Simultaneous Pancreas-Kidney Transplants

To evaluate the risk factors for pancreas graft loss within 3 months postoperatively among 170 simultaneous pancreas kidney transplantation (SPKT) we examined 38 variables. Methods. Twenty-two variables were related to recipients; 12 to donors and 4 to the surgical procedure. In addition the latest follow-up dates as well as the transplant and/or death dates. Independent variables were examined with reference to the dependent pancreatic loss variable, excluding losses owing to deaths. Variables with statistical significance were analyzed to predict early graft loss. Results. Univariate analyses determined the following significant variables: kidney cold ischemia time, older donors, non-white donors, death cause related to vascular disease, wound infection, and length of extended hospitalization. However, multivariate analysis showed that only donor age and kidney cold ischemia time were significant predictors for early pancreastic graft loss. Conclusion. Donor age and kidney cold ischemia time were independently related to pancreatic loss after SPKT within 3 months posttransplantation.