Treatment of chronic cough: P2X3 receptor antagonists and beyond

被引：16

作者：

Sykes, Dominic L. ^{[1
]}

Zhang, Mengru ^{[1
]}

Morice, Alyn H. ^{[1
]}

机构：

[1] Hull York Med Sch, Resp Res Grp, Kingston Upon Hull, N Humberside, England

来源：

PHARMACOLOGY & THERAPEUTICS | 2022年 / 237卷

关键词：

Cough; Gefapixant; Purinergic receptors; ATP; REFRACTORY CHRONIC COUGH; NUCLEUS-TRACTUS-SOLITARII; CAPSAICIN-INDUCED COUGH; ION-CHANNEL; DOUBLE-BLIND; HYPERSENSITIVITY SYNDROME; ANTITUSSIVE ACTIVITY; AIRWAY REFLUX; TRP CHANNELS; PAIN;

D O I：

10.1016/j.pharmthera.2022.108166

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

For years chronic cough (CC) has presented an enormous physical, psychological, and social burden on those who experience it, with no approved pharmacological therapies to assuage their symptoms. With our improved understanding of the pathophysiological mechanisms of CC, primarily the recognition of neuronal dysregulation in its aetiology, there appears to be a new hope for such patients. In this review we discuss the multitude of proposed pharmacological targets in CC, including the promising results produced by the antagonism of P2X3 receptors. We also assess the evidence of other peripherally acting pharmacolgical agents still in development.(c) 2022 Elsevier Inc. All rights reserved.

引用

页数：9

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